TY - JOUR
T1 - Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs
T2 - role of size and surface properties
AU - Hamoir, Julien
AU - Nemmar, Abderraim
AU - Halloy, David
AU - Wirth, Delphine
AU - Vincke, Gregoire
AU - Vanderpasschen, Alain
AU - Nemery, Benoit
AU - Gustin, Pascal
PY - 2003
Y1 - 2003
N2 - The aim of this study was to investigate the role of particle number, total surface area, mass and surface chemical groups in (Kf,c) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pulmonary microvascular permeability (Kf,c) modifications were measured in response to intratracheal particle challenge. Polystyrene particles, mainly located in alveolar spaces and macrophages, induced a Kf,c increase that was related to the total surface area and number of particles rather than to the instilled mass. Moreover, the positively charged amine-modified polystyrene particles were more effective in the Kf,c response than the negatively charged carboxylate-modified polystyrene particles. We concluded that particle number and diameter that mathematically equally determined total surface area do not have the same importance in explaining the biological effects observed and that particle number could be an alternative to total surface area to describe the particle exposure. Furthermore, surface properties of polystyrene particles need to be considered to investigate the microvascular permeability changes measured in our model.
AB - The aim of this study was to investigate the role of particle number, total surface area, mass and surface chemical groups in (Kf,c) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pulmonary microvascular permeability (Kf,c) modifications were measured in response to intratracheal particle challenge. Polystyrene particles, mainly located in alveolar spaces and macrophages, induced a Kf,c increase that was related to the total surface area and number of particles rather than to the instilled mass. Moreover, the positively charged amine-modified polystyrene particles were more effective in the Kf,c response than the negatively charged carboxylate-modified polystyrene particles. We concluded that particle number and diameter that mathematically equally determined total surface area do not have the same importance in explaining the biological effects observed and that particle number could be an alternative to total surface area to describe the particle exposure. Furthermore, surface properties of polystyrene particles need to be considered to investigate the microvascular permeability changes measured in our model.
U2 - 10.1016/S0041-008X(03)00192-3
DO - 10.1016/S0041-008X(03)00192-3
M3 - Article
SN - 0041-008X
VL - 190
SP - 278
EP - 285
JO - Toxicology and applied pharmacology
JF - Toxicology and applied pharmacology
IS - 3
ER -