Effect of P39 Gene Deletion in LiveBrucella Vaccine Strains on Residual Virulence and Protective Activity in Mice

Anne Tibor; Isabelle Jacques; Laurence Guilloteau; Jean-Michel Verger; Maggy Grayon; Valerie Wansard; Jean-Jacques Letesson

doi:10.1128/iai.66.11.5561-5564.1998

Effect of P39 Gene Deletion in LiveBrucella Vaccine Strains on Residual Virulence and Protective Activity in Mice

Anne Tibor, Isabelle Jacques, Laurence Guilloteau, Jean-Michel Verger, Maggy Grayon, Valerie Wansard, Jean-Jacques Letesson (Supervisor)

Research output: Contribution to journal › Article

Abstract

The 39-kilodalton protein (P39) has previously been shown to be an immunodominant protein in Brucella infections. P39 gene deletion mutants of vaccine strains Brucella abortus S19 and Brucella melitensis Rev.1 were constructed by gene replacement. This deletion did not significantly modify the residual virulence of both vaccine strains in CD-1 mice. CD-1 mice vaccinated with the parent or mutant strains were protected against a virulent challenge. Mutant vaccine strains devoid of P39 could provide a means for differentiating vaccinated from infected animals.

Original language	English
Pages (from-to)	5561-5564
Number of pages	4
Journal	Infection and Immunity
Volume	66
Issue number	11
DOIs	https://doi.org/10.1128/iai.66.11.5561-5564.1998
Publication status	Published - 1998

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10.1128/iai.66.11.5561-5564.1998

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title = "Effect of P39 Gene Deletion in LiveBrucella Vaccine Strains on Residual Virulence and Protective Activity in Mice",

abstract = "The 39-kilodalton protein (P39) has previously been shown to be an immunodominant protein in Brucella infections. P39 gene deletion mutants of vaccine strains Brucella abortus S19 and Brucella melitensis Rev.1 were constructed by gene replacement. This deletion did not significantly modify the residual virulence of both vaccine strains in CD-1 mice. CD-1 mice vaccinated with the parent or mutant strains were protected against a virulent challenge. Mutant vaccine strains devoid of P39 could provide a means for differentiating vaccinated from infected animals.",

author = "Anne Tibor and Isabelle Jacques and Laurence Guilloteau and Jean-Michel Verger and Maggy Grayon and Valerie Wansard and Jean-Jacques Letesson",

year = "1998",

doi = "10.1128/iai.66.11.5561-5564.1998",

language = "English",

volume = "66",

pages = "5561--5564",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Effect of P39 Gene Deletion in LiveBrucella Vaccine Strains on Residual Virulence and Protective Activity in Mice

AU - Tibor, Anne

AU - Jacques, Isabelle

AU - Guilloteau, Laurence

AU - Verger, Jean-Michel

AU - Grayon, Maggy

AU - Wansard, Valerie

A2 - Letesson, Jean-Jacques

PY - 1998

Y1 - 1998

N2 - The 39-kilodalton protein (P39) has previously been shown to be an immunodominant protein in Brucella infections. P39 gene deletion mutants of vaccine strains Brucella abortus S19 and Brucella melitensis Rev.1 were constructed by gene replacement. This deletion did not significantly modify the residual virulence of both vaccine strains in CD-1 mice. CD-1 mice vaccinated with the parent or mutant strains were protected against a virulent challenge. Mutant vaccine strains devoid of P39 could provide a means for differentiating vaccinated from infected animals.

AB - The 39-kilodalton protein (P39) has previously been shown to be an immunodominant protein in Brucella infections. P39 gene deletion mutants of vaccine strains Brucella abortus S19 and Brucella melitensis Rev.1 were constructed by gene replacement. This deletion did not significantly modify the residual virulence of both vaccine strains in CD-1 mice. CD-1 mice vaccinated with the parent or mutant strains were protected against a virulent challenge. Mutant vaccine strains devoid of P39 could provide a means for differentiating vaccinated from infected animals.

U2 - 10.1128/iai.66.11.5561-5564.1998

DO - 10.1128/iai.66.11.5561-5564.1998

M3 - Article

SN - 0019-9567

VL - 66

SP - 5561

EP - 5564

JO - Infection and Immunity

JF - Infection and Immunity

IS - 11

ER -

Effect of P39 Gene Deletion in LiveBrucella Vaccine Strains on Residual Virulence and Protective Activity in Mice

Abstract

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