Abstract
We investigated the effects of a dual thromboxane (TX)A2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on right ventricular-arterial coupling in a porcine model of endotoxic shock. Thirty minutes before the onset of 0.5 mg/kg endotoxin infusion, six pigs (Endo group) received an infusion with a placebo solution, and six other pigs (Anta group) with BM-573. Right ventricular pressure-volume loops were obtained by the conductance catheter technique. The slope (Ees) of the end-systolic pressure-volume relationship and its volume intercept at 25 mmHg were calculated as measures of right ventricular systolic function. RV afterload was quantified by pulmonary arterial elastance (Ea), and Ees/Ea ratio represented right ventricular-arterial coupling. Mechanical efficiency was defined as the ratio of stroke work and pressure-volume area. In this model of endotoxic shock, BM-573 blunted the early phase of pulmonary hypertension, improved arterial oxygenation, and prevented a decrease in right ventricular myocardial efficiency and right ventricular dilatation. However, the drug could not prevent the loss of homeometric regulation and alterations in right ventricular-arterial coupling. In conclusion, dual TXA2 synthase inhibitor and receptor antagonists such as BM-573 have potential therapeutic applications, improving right ventricular efficiency and arterial oxygenation in endotoxic shock.
Original language | English |
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Pages (from-to) | 45-51 |
Number of pages | 7 |
Journal | Shock (Augusta, Ga.) |
Volume | 21 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2004 |
Keywords
- Animals
- Catheterization
- Disease Models, Animal
- Endotoxins
- Female
- Heart Ventricles
- Male
- Myocardium
- Oxygen
- Pancreatic Elastase
- Placebos
- Pressure
- Pulmonary Circulation
- Shock, Septic
- Swine
- Systole
- Thromboxane A2
- Time Factors