Abstract

Owing to their phenomenal electrical and mechanical properties, carbon nanotubes (CNT) have been an area of intense research since their discovery in 1991. Different applications for these nanoparticles have been proposed, among others, in electronics and optics but also in the medical field. In parallel, emerging studies have suggested potential toxic effects of CNT while others did not, generating some conflicting outcomes. These discrepancies could be, in part, due to different suspension approaches used and to the agglomeration state of CNT in solution. In this study, we described a standardized protocol to obtain stable CNT suspensions, using two biocompatible dispersants (Pluronic F108 and hydroxypropylcellulose) and to estimate the concentration of CNT in solution. CNT appear to be greatly individualized in these two dispersants with no detection of remaining bundles or agglomerates after sonication and centrifugation. Moreover, CNT remained perfectly dispersed when added to culture medium used for in vitro cell experiments. We also showed that Pluronic F108 is a better dispersant than hydroxypropylcellulose. In conclusion, we have developed a standardized protocol using biocompatible surfactants to obtain reproducible and stable multi-walled carbon nanotubes suspensions which can be used for in vitro or in vivo toxicological studies. © 2009 Springer Science+Business Media B.V.
Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalJournal of Nanoparticle Research
Volume12
Issue number1
DOIs
Publication statusPublished - 2010

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Multi-walled Carbon Nanotubes
Carbon Nanotubes
Nanotubes
Carbon nanotubes
Carbon
carbon nanotubes
Poloxamer
Suspensions
Agglomeration
Electrical Properties
Surfactant
culture media
Sonication
Centrifugation
Poisons
Mechanical Properties
Nanoparticles
agglomeration
Discrepancy
Optics

Keywords

  • Multi-walled CNT
  • HPC
  • Centrifugation
  • Pluronic F108
  • Sonication

Cite this

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title = "Dispersion of multi-walled carbon nanotubes in biocompatible dispersants",
abstract = "Owing to their phenomenal electrical and mechanical properties, carbon nanotubes (CNT) have been an area of intense research since their discovery in 1991. Different applications for these nanoparticles have been proposed, among others, in electronics and optics but also in the medical field. In parallel, emerging studies have suggested potential toxic effects of CNT while others did not, generating some conflicting outcomes. These discrepancies could be, in part, due to different suspension approaches used and to the agglomeration state of CNT in solution. In this study, we described a standardized protocol to obtain stable CNT suspensions, using two biocompatible dispersants (Pluronic F108 and hydroxypropylcellulose) and to estimate the concentration of CNT in solution. CNT appear to be greatly individualized in these two dispersants with no detection of remaining bundles or agglomerates after sonication and centrifugation. Moreover, CNT remained perfectly dispersed when added to culture medium used for in vitro cell experiments. We also showed that Pluronic F108 is a better dispersant than hydroxypropylcellulose. In conclusion, we have developed a standardized protocol using biocompatible surfactants to obtain reproducible and stable multi-walled carbon nanotubes suspensions which can be used for in vitro or in vivo toxicological studies. {\circledC} 2009 Springer Science+Business Media B.V.",
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author = "Jean-Pascal Piret and Simon Detriche and Renaud Vigneron and Sebastien Vankoningsloo and St{\'e}phanie Rolin and {Mejia Mendoza}, {Jorge Humberto} and Bernard Masereel and Stephane Lucas and Joseph Delhalle and Fr{\'e}d{\'e}ric Luizi and Christelle Saout and Olivier Toussaint",
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T1 - Dispersion of multi-walled carbon nanotubes in biocompatible dispersants

AU - Piret, Jean-Pascal

AU - Detriche, Simon

AU - Vigneron, Renaud

AU - Vankoningsloo, Sebastien

AU - Rolin, Stéphanie

AU - Mejia Mendoza, Jorge Humberto

AU - Masereel, Bernard

AU - Lucas, Stephane

AU - Delhalle, Joseph

AU - Luizi, Frédéric

AU - Saout, Christelle

AU - Toussaint, Olivier

N1 - Publication code : RES. ACAD.

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KW - Multi-walled CNT

KW - HPC

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