To assess the significance of asynchronous left ventricular wall motion during diastole in chronic volume overload, left ventricular systolic and diastolic functions were analyzed in 18 patients with valvular regurgitation. Regional wall motion and peak filling rates were computed in eight left ventricular segments. Regional peak filling rate and time to peak filling rate were normal in eight patients (Group A), but in ten patients (Group B), the time to peak filling rate was prolonged at an average of 2. 7 segments/patient and the peak filling rate was depressed at an average of 1. 6 segments/patient. Ejection fraction was only slightly lower in B (60 plus or minus 11 vs. 68 plus or minus 9% in A; NS) but the indices of contractility, such as the slope of the mean velocity of shortening-mean systolic wall stress relation, indicated a depressed contractility in Group B. It is concluded that in valvular regurgitation, asynchronous left ventricular filling might be a sensitive marker of depressed contractility during follow-up studies.