Developmental profiles of GFAP-positive astrocytes in sheep cerebellum

Moustafa Salouci, Nadine Antoine, Mohamad Khir Shikh Al Sook, Joëlle Piret, Yvan Mignon, Nathalie Kirschvink, Annick Gabriel

Research output: Contribution to journalArticle

Abstract

Astroglial account for the largest glial population in the brain and play a variety of vital functions in the development of the central nervous system (CNS). An immunohistochemical study was performed in 19 ovine foetuses ranging from 2 to 5 months of gestation, one newborn lamb and three adult sheep. Using the anit-glial fibrillary acidic protein (GFAP) marker, several variations were found in the degree of GFAP positive (GFAP+) astrocyte distribution between the different zones in the cerebellum of sheep during brain development. Our study indicates that the first appearance of astrocytes from restricted zones in the cerebellum occurs around the eighth week of gestation. Bergmann cells were found to be present from around the 15th week of gestation onwards. Our findings suggest that the maturation of astrocytes begins in the caudal parts of the cerebellum, developing from their initial ventral regions to spread first to dorsal regions radially within the white matter, then followed by the more rostral parts of the cerebellum. Astrocytes were also found to proliferate in the vermis before appearing in the cerebellar hemispheres.

Original languageEnglish
JournalVeterinary Research Communications
DOIs
Publication statusAccepted/In press - 13 Aug 2014

Fingerprint

astrocytes
Glial Fibrillary Acidic Protein
neuroglia
cerebellum
Astrocytes
Cerebellum
Sheep
sheep
pregnancy
Pregnancy
proteins
brain
neurodevelopment
Brain
Neuroglia
fetus
neonates
Fetus
lambs
Central Nervous System

Keywords

  • Astrocytes
  • Brain development
  • Cerebellum
  • Immunohistochemistry
  • Sheep

Cite this

Salouci, Moustafa ; Antoine, Nadine ; Shikh Al Sook, Mohamad Khir ; Piret, Joëlle ; Mignon, Yvan ; Kirschvink, Nathalie ; Gabriel, Annick. / Developmental profiles of GFAP-positive astrocytes in sheep cerebellum. In: Veterinary Research Communications. 2014.
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Developmental profiles of GFAP-positive astrocytes in sheep cerebellum. / Salouci, Moustafa; Antoine, Nadine; Shikh Al Sook, Mohamad Khir; Piret, Joëlle; Mignon, Yvan; Kirschvink, Nathalie; Gabriel, Annick.

In: Veterinary Research Communications, 13.08.2014.

Research output: Contribution to journalArticle

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AU - Antoine, Nadine

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