Developmental expression profiles of Celsr (Flamingo) genes in the mouse

Fadel Afathi Tissir, Olivier De Backer, André Goffinet, Catherine Lambert De Rouvroit

Research output: Contribution to journalArticle


Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.
Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalMechanisms of development
Publication statusPublished - 2002


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