Developmental expression profiles of Celsr (Flamingo) genes in the mouse

Fadel Afathi Tissir, Olivier De Backer, André Goffinet, Catherine Lambert De Rouvroit

Research output: Contribution to journalArticle

Abstract

Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.
Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalMechanisms of development
Volume112
Publication statusPublished - 2002

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Cadherins
Genes
Cell Polarity
Brain
Drosophila
Rodentia
Proteins
Epithelium
Epithelial Cells

Cite this

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title = "Developmental expression profiles of Celsr (Flamingo) genes in the mouse",
abstract = "Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.",
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Developmental expression profiles of Celsr (Flamingo) genes in the mouse. / Tissir, Fadel Afathi; De Backer, Olivier; Goffinet, André; Lambert De Rouvroit, Catherine.

In: Mechanisms of development, Vol. 112, 2002, p. 157-160.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Developmental expression profiles of Celsr (Flamingo) genes in the mouse

AU - Tissir, Fadel Afathi

AU - De Backer, Olivier

AU - Goffinet, André

AU - Lambert De Rouvroit, Catherine

PY - 2002

Y1 - 2002

N2 - Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.

AB - Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.

M3 - Article

VL - 112

SP - 157

EP - 160

JO - Mechanisms of development

JF - Mechanisms of development

SN - 0925-4773

ER -