TY - GEN
T1 - Deep Learning approach predicting breast tumor response to neoadjuvant treatment using DCE-MRI volumes acquired before and after chemotherapy
AU - El Adoui, Mohammed
AU - Larhmam, Mohamed Amine
AU - Drisis, Stylianos
AU - Benjelloun, Mohammed
N1 - Publisher Copyright:
© 2019 SPIE.
PY - 2019
Y1 - 2019
N2 - Purpose: In breast cancer medical follow-up, due to the lack of specialized aided diagnosis tools, many breast cancer patients may continue to receive chemotherapy even if they do not respond to the treatment. In this work, we propose a new approach for early prediction of breast cancer response to chemotherapy from two follow-up DCE-MRI exams. We present a method that takes advantage of a deep convolutional neural network (CNN) model to classify patients who are responsive or non-responsive to chemotherapy. Methods and material: To provide an early prediction of breast cancer response to chemotherapy, we used a two branch Convolution Neural Network (CNN) architecture, taking as inputs two breast tumor MRI slices acquired before and after the first round of chemotherapy. We trained our model on a 693 x 2 ROIs belonging to 42 patients with local breast cancer. Image pretreatment, volumetric image registration and tumor segmentation were applied to MRI exams as a preprocessing step. As a ground truth, we used the anapathological standard reference provided of each patient. Results: Within 80 training epochs, an accuracy of 92.72% was obtained using 20% as validation data. The Area Under the Curve (AUC) was 0.96. Conclusion: In this paper, it was demonstrated that deep CNNs models can be used to solve breast cancer follow-up related problems. Therefore, the model obtained in this work can be exploited in future clinical applications after improving its efficiency with the used data.
AB - Purpose: In breast cancer medical follow-up, due to the lack of specialized aided diagnosis tools, many breast cancer patients may continue to receive chemotherapy even if they do not respond to the treatment. In this work, we propose a new approach for early prediction of breast cancer response to chemotherapy from two follow-up DCE-MRI exams. We present a method that takes advantage of a deep convolutional neural network (CNN) model to classify patients who are responsive or non-responsive to chemotherapy. Methods and material: To provide an early prediction of breast cancer response to chemotherapy, we used a two branch Convolution Neural Network (CNN) architecture, taking as inputs two breast tumor MRI slices acquired before and after the first round of chemotherapy. We trained our model on a 693 x 2 ROIs belonging to 42 patients with local breast cancer. Image pretreatment, volumetric image registration and tumor segmentation were applied to MRI exams as a preprocessing step. As a ground truth, we used the anapathological standard reference provided of each patient. Results: Within 80 training epochs, an accuracy of 92.72% was obtained using 20% as validation data. The Area Under the Curve (AUC) was 0.96. Conclusion: In this paper, it was demonstrated that deep CNNs models can be used to solve breast cancer follow-up related problems. Therefore, the model obtained in this work can be exploited in future clinical applications after improving its efficiency with the used data.
KW - Breast cancer
KW - Deep learning
KW - Early tumor response prediction
KW - MRI images
UR - http://www.scopus.com/inward/record.url?scp=85068132613&partnerID=8YFLogxK
U2 - 10.1117/12.2505887
DO - 10.1117/12.2505887
M3 - Conference contribution
AN - SCOPUS:85068132613
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2019
A2 - Mori, Kensaku
A2 - Hahn, Horst K.
PB - SPIE
T2 - Medical Imaging 2019: Computer-Aided Diagnosis
Y2 - 17 February 2019 through 20 February 2019
ER -