Deciphering the roles of ABCB5 in normal and cancer cells

Laurent Duvivier; Jean Pierre Gillet

doi:10.1016/j.trecan.2022.07.001

Deciphering the roles of ABCB5 in normal and cancer cells

Research output: Contribution to journal › Short survey › peer-review

Abstract

ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.

Original language	English
Pages (from-to)	795-798
Number of pages	4
Journal	Trends in Cancer
Volume	8
Issue number	10
DOIs	https://doi.org/10.1016/j.trecan.2022.07.001
Publication status	Published - Oct 2022
Externally published	Yes

Funding

The authors are grateful to Michael M. Gottesman (Laboratory of Cell Biology, Center for Cancer Research, NCI-NIH, USA) for his critical reading of the manuscript. No interests are declared.

Keywords

ABCB5
melanocyte biology
melanoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trecan.2022.07.001

Cite this

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title = "Deciphering the roles of ABCB5 in normal and cancer cells",

abstract = "ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.",

keywords = "ABCB5, melanocyte biology, melanoma",

author = "Laurent Duvivier and Gillet, \{Jean Pierre\}",

note = "Funding Information: The authors are grateful to Michael M. Gottesman (Laboratory of Cell Biology, Center for Cancer Research, NCI-NIH, USA) for his critical reading of the manuscript. No interests are declared. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

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doi = "10.1016/j.trecan.2022.07.001",

language = "English",

volume = "8",

pages = "795--798",

journal = "Trends in Cancer",

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TY - JOUR

T1 - Deciphering the roles of ABCB5 in normal and cancer cells

AU - Duvivier, Laurent

AU - Gillet, Jean Pierre

N1 - Funding Information: The authors are grateful to Michael M. Gottesman (Laboratory of Cell Biology, Center for Cancer Research, NCI-NIH, USA) for his critical reading of the manuscript. No interests are declared. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/10

Y1 - 2022/10

N2 - ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.

AB - ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.

KW - ABCB5

KW - melanocyte biology

KW - melanoma

UR - https://www.scopus.com/pages/publications/85135041489

U2 - 10.1016/j.trecan.2022.07.001

DO - 10.1016/j.trecan.2022.07.001

M3 - Short survey

AN - SCOPUS:85135041489

SN - 2405-8033

VL - 8

SP - 795

EP - 798

JO - Trends in Cancer

JF - Trends in Cancer

IS - 10

ER -

Deciphering the roles of ABCB5 in normal and cancer cells

Abstract

Funding

Keywords

UN SDGs

Access to Document

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