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Abstract
D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.
Original language | English |
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Article number | 2770 |
Journal | Diagnostics |
Volume | 12 |
Issue number | 11 |
DOIs | |
Publication status | Published - 12 Nov 2022 |
Keywords
- analytical
- D-dimer
- In Vitro Diagnostic Regulation
- ISO15189
- post-analytical
- pre-analytical
- pulmonary embolism
- venous thromboembolism
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Dive into the research topics of 'D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review'. Together they form a unique fingerprint.Projects
- 1 Active
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Clinical Pharmacology Research Group
Douxfils, J. (Supervisor), Dogné, J.-M. (Supervisor), Musuamba Tshinanu, F. (Supervisor), Masereel, B. (Supervisor), Wieërs, G. (Supervisor), Haguet, H. (Researcher), RONVAUX, L. (Researcher), Donis, N. (Researcher), Morimont, L. (Researcher), Evrard, J. (Researcher), Siriez, R. (Researcher), Gillot, C. (Researcher), FAVRESSE, J. (Researcher), BOUVY, C. (Researcher), Djokoto, H. (Researcher), Didembourg, M. (Researcher), David, C. (Support role), Melchionda, S. (Support role), Maloteau, V. (Technician), Boucher, A.-Y. (Technician), Devel, P. (Technician), Modaffari, E. (Technician), Vandeputte, M. (Technician), De Messemaeker, A. (Secretaire), Decarpentrie, J. (Researcher), Vassart, J. (Researcher) & De Groote, A. (Researcher)
1/04/22 → …
Project: Research Axis
Press/Media
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Department of Laboratory Medicine Researchers Provide New Data on Pulmonary Embolism (D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review)
9/12/22
1 item of Media coverage
Press/Media: Expert Comment