Cortical reactivations during sleep spindles following declarative learning

Aude Jegou, Manuel Schabus, Olivia Gosseries, Brigitte Dahmen, Geneviève Albouy, Martin Desseilles, Virginie Sterpenich, Christophe Phillips, Pierre Maquet, Christophe Grova, Thien Thanh Dang-Vu

Research output: Contribution to journalArticle

Abstract

Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.

Original languageEnglish
Pages (from-to)104-112
Number of pages9
JournalNeuroImage
Volume195
DOIs
Publication statusPublished - 15 Jul 2019

Fingerprint

Sleep
Learning
Electroencephalography
Magnetic Resonance Imaging
Temporal Lobe
Brain
Healthy Volunteers
Memory Consolidation

Keywords

  • Consolidation
  • EEG/fMRI
  • Memory
  • Oscillations
  • Replay
  • Sleep

Cite this

Jegou, A., Schabus, M., Gosseries, O., Dahmen, B., Albouy, G., Desseilles, M., ... Dang-Vu, T. T. (2019). Cortical reactivations during sleep spindles following declarative learning. NeuroImage, 195, 104-112. https://doi.org/10.1016/j.neuroimage.2019.03.051
Jegou, Aude ; Schabus, Manuel ; Gosseries, Olivia ; Dahmen, Brigitte ; Albouy, Geneviève ; Desseilles, Martin ; Sterpenich, Virginie ; Phillips, Christophe ; Maquet, Pierre ; Grova, Christophe ; Dang-Vu, Thien Thanh. / Cortical reactivations during sleep spindles following declarative learning. In: NeuroImage. 2019 ; Vol. 195. pp. 104-112.
@article{b506f53b4991419ea6d7ed7aefb94e53,
title = "Cortical reactivations during sleep spindles following declarative learning",
abstract = "Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.",
keywords = "Consolidation, EEG/fMRI, Memory, Oscillations, Replay, Sleep",
author = "Aude Jegou and Manuel Schabus and Olivia Gosseries and Brigitte Dahmen and Genevi{\`e}ve Albouy and Martin Desseilles and Virginie Sterpenich and Christophe Phillips and Pierre Maquet and Christophe Grova and Dang-Vu, {Thien Thanh}",
year = "2019",
month = "7",
day = "15",
doi = "10.1016/j.neuroimage.2019.03.051",
language = "English",
volume = "195",
pages = "104--112",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

Jegou, A, Schabus, M, Gosseries, O, Dahmen, B, Albouy, G, Desseilles, M, Sterpenich, V, Phillips, C, Maquet, P, Grova, C & Dang-Vu, TT 2019, 'Cortical reactivations during sleep spindles following declarative learning', NeuroImage, vol. 195, pp. 104-112. https://doi.org/10.1016/j.neuroimage.2019.03.051

Cortical reactivations during sleep spindles following declarative learning. / Jegou, Aude; Schabus, Manuel; Gosseries, Olivia; Dahmen, Brigitte; Albouy, Geneviève; Desseilles, Martin; Sterpenich, Virginie; Phillips, Christophe; Maquet, Pierre; Grova, Christophe; Dang-Vu, Thien Thanh.

In: NeuroImage, Vol. 195, 15.07.2019, p. 104-112.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cortical reactivations during sleep spindles following declarative learning

AU - Jegou, Aude

AU - Schabus, Manuel

AU - Gosseries, Olivia

AU - Dahmen, Brigitte

AU - Albouy, Geneviève

AU - Desseilles, Martin

AU - Sterpenich, Virginie

AU - Phillips, Christophe

AU - Maquet, Pierre

AU - Grova, Christophe

AU - Dang-Vu, Thien Thanh

PY - 2019/7/15

Y1 - 2019/7/15

N2 - Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.

AB - Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.

KW - Consolidation

KW - EEG/fMRI

KW - Memory

KW - Oscillations

KW - Replay

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=85063758399&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2019.03.051

DO - 10.1016/j.neuroimage.2019.03.051

M3 - Article

C2 - 30928690

AN - SCOPUS:85063758399

VL - 195

SP - 104

EP - 112

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -