Abstract
Structural, electronic, and lipophilicity characteristics of dihydro-2,3-methoxy-4 and dihydro-2,3[(phenylmethyl)-8 aza-8 bicyclo[3.2.1.] octyl-3]-2 1H-isoindolone-1, (exo), two conformationally restricted nortropane benzamide derivatives (subgroup of neuroleptic drugs) have been determined and compared to other more “flexible” analogs in order to explain their pharmacological antidopaminergic D2 activities. Molecular structures of both compounds were obtained using single crystal X-ray crystallography; molecular electrostatic potential maps were computed at theab initio MO STO-3G level, and the capacity factors were measured by RP-HPLC.
Original language | English |
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Pages (from-to) | 431-443 |
Number of pages | 13 |
Journal | Journal of Crystallographic and Spectrosccopic Research |
Volume | 21 |
DOIs | |
Publication status | Published - 1991 |