Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays

A.-C. Wéra, C. Borlon, V.E. Nuttens, S. Lucas, H. Riquier, C. Michiels, O. Feron

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Abstract

Purpose: Lung cancer is the leading cause of cancer-related death. Among the new modalities to treat cancer, internal radiotherapy seems to be very promising. However, the achievable dose-rate is two orders of magnitude lower than the one used in conventional external radiotherapy, and data has to be collected to evaluate the cell response to highlight the potential effectiveness of low-dose-rate beta particles irradiation. This work investigates the phosphorus beta irradiation ( P) dose response on the clonogenicity of human A549 non-small cell lung adenocarcinoma cells and compares it to high-dose-rate X-irradiations results. Materials and methods: Cell survival was evaluated by a colony forming assay eight days after low-dose-rate P beta irradiations (0.8 Gy/h) and high-dose-rate X-ray irradiations (0.855 Gy/min). Results: Survival curves were obtained for both types of irradiations, and showed hyper-radiosensitivity at very low doses. Radiosensitivity parameters were obtained by using the linear-quadratic and induced-repair models. Conclusions: Comparison with high-dose-rate X-rays shows a similar surviving fraction, confirming the effectiveness of beta particles for tumor sterilization.
Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalInternational Journal of Radiation Biology
Volume88
Issue number3
DOIs
Publication statusPublished - 2012

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  • Activities

    • 2 Participation in conference

    2nd BHTC workshop ; Hadrontherapy: from cell to patient

    Stéphane Lucas (Organiser)

    23 May 2014

    Activity: Participating in or organising an event typesParticipation in conference

    11th International Topical Meeting on Nuclera Applications of Accelerators (AccApp2013)

    Stéphane Lucas (Member of Organizing Committee)

    5 Aug 20138 Aug 2013

    Activity: Participating in or organising an event typesParticipation in conference

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