Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Dario Braga; Fabrizia Grepioni; Lucia Maini; Davide Capucci; Saverio Nanna; Johan Wouters; Luc Aerts; Luc Quéré

doi:10.1039/c2cc33855f

Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Dario Braga, Fabrizia Grepioni, Lucia Maini, Davide Capucci, Saverio Nanna, Johan Wouters, Luc Aerts, Luc Quéré

Research output: Contribution to journal › Article › peer-review

Abstract

Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

Original language	English
Pages (from-to)	8219-8221
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	66
DOIs	https://doi.org/10.1039/c2cc33855f
Publication status	Published - 25 Aug 2012

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10.1039/c2cc33855f

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abstract = "Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.",

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AU - Braga, Dario

AU - Grepioni, Fabrizia

AU - Maini, Lucia

AU - Capucci, Davide

AU - Nanna, Saverio

AU - Wouters, Johan

AU - Aerts, Luc

AU - Quéré, Luc

PY - 2012/8/25

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N2 - Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

AB - Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

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Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Abstract

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Physical Chemistry and characterization(PC2)

CCDC 884810: Experimental Crystal Structure Determination

CCDC 884811: Experimental Crystal Structure Determination

CCDC 884812: Experimental Crystal Structure Determination

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Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Abstract

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Physical Chemistry and characterization(PC2)

Datasets

CCDC 884810: Experimental Crystal Structure Determination

CCDC 884811: Experimental Crystal Structure Determination

CCDC 884812: Experimental Crystal Structure Determination

Cite this