Close-packed array of gold nanoparticles and Sum Frequency Generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors

G. Tourillon; L. Dreesen; C. Volcke; Y. Sartenaer; P.A. Thiry; A. Peremans

doi:10.1007/s10853-009-3572-y

Close-packed array of gold nanoparticles and Sum Frequency Generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors

G. Tourillon, L. Dreesen, C. Volcke, Y. Sartenaer, P.A. Thiry, A. Peremans

Research output: Contribution to journal › Article › peer-review

Abstract

An approach is introduced for studying the adsorption and recognition mechanisms of biomolecules, without using any markers. We show for the first time, that the sum frequency generation spectroscopy performed in the total internal reflection (TIR-SFG) geometry, combined with a regular close-packed array of gold nanoparticles allows to probe with a high sensitivity the changes in conformation and orientation induced by the recognition process of avidin by biocytin. This approach represents a new platform with potential use in biosensors, diagnostics and bioactive layers. © 2009 Springer Science+Business Media, LLC.

Original language	English
Pages (from-to)	6805-6810
Number of pages	6
Journal	Journal of Materials Science
Volume	44
Issue number	24
DOIs	https://doi.org/10.1007/s10853-009-3572-y
Publication status	Published - 1 Jan 2009

Keywords

avidin.
Biosensors
sum frequency generation spectroscopy
nanoparticles
biocytin

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abstract = "An approach is introduced for studying the adsorption and recognition mechanisms of biomolecules, without using any markers. We show for the first time, that the sum frequency generation spectroscopy performed in the total internal reflection (TIR-SFG) geometry, combined with a regular close-packed array of gold nanoparticles allows to probe with a high sensitivity the changes in conformation and orientation induced by the recognition process of avidin by biocytin. This approach represents a new platform with potential use in biosensors, diagnostics and bioactive layers. {\textcopyright} 2009 Springer Science+Business Media, LLC.",

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AU - Dreesen, L.

AU - Volcke, C.

AU - Sartenaer, Y.

AU - Thiry, P.A.

AU - Peremans, A.

PY - 2009/1/1

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AB - An approach is introduced for studying the adsorption and recognition mechanisms of biomolecules, without using any markers. We show for the first time, that the sum frequency generation spectroscopy performed in the total internal reflection (TIR-SFG) geometry, combined with a regular close-packed array of gold nanoparticles allows to probe with a high sensitivity the changes in conformation and orientation induced by the recognition process of avidin by biocytin. This approach represents a new platform with potential use in biosensors, diagnostics and bioactive layers. © 2009 Springer Science+Business Media, LLC.

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KW - Biosensors

KW - sum frequency generation spectroscopy

KW - nanoparticles

KW - biocytin

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JF - Journal of Materials Science

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Close-packed array of gold nanoparticles and Sum Frequency Generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors

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