Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam

Xavier Buol, Camila Caro Garrido, Koen Robeyns, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98-99%) was obtained with a process that can run for multiple cycles.

Original languageEnglish
Pages (from-to)7979-7988
Number of pages10
JournalCrystal Growth and Design
Volume20
Issue number12
Early online date9 Nov 2020
DOIs
Publication statusPublished - 2 Dec 2020

Fingerprint Dive into the research topics of 'Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam'. Together they form a unique fingerprint.

Cite this