TY - JOUR
T1 - Chemical constituents from Psychotria arborea Hiern (Rubiaceae)
AU - Ngo Nyobe, Judith Caroline
AU - Tekapi Tsopgni, Willifred Dongmo
AU - Longue Ekon, Jean Pierre
AU - Ben Saida, Ali
AU - Djuidje, Annie Guilaine
AU - Bengondo, Anicet Biwole
AU - Etame Loe, Gisele
AU - Berionni, Guillaume
AU - Mama, Desire Bikele
AU - Ndom, Jean Claude
AU - Mpondo, Emmanuel Mpondo
N1 - Funding Information:
The authors are grateful to Damien Mahaut and Xavier Maes of the Reactivity and Organic catalysis laboratory in the University of Namur for the NMR and MS measurements. We also thank Pr. Beno?t CHAMPAGNE for his support.
Publisher Copyright:
© 2020
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - The chemical study of the stems extract of Psychotria arborea Hiern led to the isolation of thirteen compounds, including four anthraquinones: 2-methylanthracene-9,10-dione (1), 2-methoxyanthracene-9,10-dione (2), 2-hydroxy-3-methylanthracene-9,10-dione (3) and 3-hydroxy-1-methoxy-2-methylanthracene-9,10-dione (4); two diterpenes: ent-kaur-16-en-19-oic acid (5) and 15-acetoxy-ent-kaur-16-en-19-oic acid (6); two triterpenes, β-amyrin (8) and oleanolic acid (9), one flavonoid: Quercetin (7), three sterols: A mixture of stigmasterol (10) and β-sitosterol (11) and β-sitosterol-3-O-β-D-glucopyranoside (12) and one fatty acid (13). The structures of these compounds were elucidated based on NMR and HR-ESIMS analysis, further supported by comparison with previously reported spectral data. Compounds 1–4 and compounds 10–12 were tested for their antibacterial activity against three bacteria strains Escherichia coli, Staphylococcus aureus and Salmonella enterica. All these tested compounds were found to be inactive. Furthermore, the chemotaxonomic significance of the obtained compounds was discussed in detail.
AB - The chemical study of the stems extract of Psychotria arborea Hiern led to the isolation of thirteen compounds, including four anthraquinones: 2-methylanthracene-9,10-dione (1), 2-methoxyanthracene-9,10-dione (2), 2-hydroxy-3-methylanthracene-9,10-dione (3) and 3-hydroxy-1-methoxy-2-methylanthracene-9,10-dione (4); two diterpenes: ent-kaur-16-en-19-oic acid (5) and 15-acetoxy-ent-kaur-16-en-19-oic acid (6); two triterpenes, β-amyrin (8) and oleanolic acid (9), one flavonoid: Quercetin (7), three sterols: A mixture of stigmasterol (10) and β-sitosterol (11) and β-sitosterol-3-O-β-D-glucopyranoside (12) and one fatty acid (13). The structures of these compounds were elucidated based on NMR and HR-ESIMS analysis, further supported by comparison with previously reported spectral data. Compounds 1–4 and compounds 10–12 were tested for their antibacterial activity against three bacteria strains Escherichia coli, Staphylococcus aureus and Salmonella enterica. All these tested compounds were found to be inactive. Furthermore, the chemotaxonomic significance of the obtained compounds was discussed in detail.
KW - 2-Methylanthracene-9,10-dione
KW - Anthraquinones
KW - Antibacterial activities
KW - Psychotria arborea
KW - Rubiaceae
UR - http://www.scopus.com/inward/record.url?scp=85098212473&partnerID=8YFLogxK
U2 - 10.1016/j.bse.2020.104212
DO - 10.1016/j.bse.2020.104212
M3 - Article
AN - SCOPUS:85098212473
VL - 94
JO - Biochemical Systematics and Ecology
JF - Biochemical Systematics and Ecology
SN - 0305-1978
M1 - 104212
ER -