Cerebral correlates of delta waves during non-REM sleep revisited

Thien Thanh Dang-Vu, Martin Desseilles, Steven Laureys, Christian Degueldre, Fabien Perrin, Christophe Phillips, Pierre Maquet, Philippe Peigneux

Research output: Contribution to journalArticle

Abstract

We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement (NREM) sleep in non-sleep-deprived normal young adults, based on the statistical analysis of a positron emission tomography (PET) sleep data set. One hundred fifteen PET scans were obtained using H(2)(15)O under continuous polygraphic monitoring during stages 2-4 of NREM sleep. Correlations between regional cerebral blood flow (rCBF) and delta power (1.5-4 Hz) spectral density were analyzed using statistical parametric mapping (SPM2). Delta power values obtained at central scalp locations negatively correlated during NREM sleep with rCBF in the ventromedial prefrontal cortex, the basal forebrain, the striatum, the anterior insula, and the precuneus. These regions embrace the set of brain areas in which rCBF decreases during slow wave sleep (SWS) as compared to Rapid Eye Movement (REM) sleep and wakefulness (Maquet, P., Degueldre, C., Delfiore, G., Aerts, J., Peters, J.M., Luxen, A., Franck, G., 1997. Functional neuroanatomy of human slow wave sleep. J. Neurosci. 17, 2807-S2812), supporting the notion that delta activity is a valuable prominent feature of NREM sleep. A strong association was observed between rCBF in the ventromedial prefrontal regions and delta power, in agreement with electrophysiological studies. In contrast to the results of a previous PET study investigating the brain correlates of delta activity (Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A.C., Jones, B.E., 1997. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J. Neurosci. 17, 4800-4808), in which waking scans were mixed with NREM sleep scans, no correlation was found with thalamus activity. This latter result stresses the importance of an extra-thalamic delta rhythm among the synchronous NREM sleep oscillations. Consequently, this rCBF distribution might preferentially reflect a particular modulation of the cellular processes involved in the generation of cortical delta waves during NREM sleep.
Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalNeuroImage
Volume28
Issue number1
DOIs
Publication statusPublished - 15 Oct 2005

Fingerprint

Eye Movements
Cerebrovascular Circulation
Sleep
REM Sleep
Regional Blood Flow
Positron-Emission Tomography
Delta Rhythm
Neuroanatomy
Parietal Lobe
Wakefulness
Brain
Prefrontal Cortex
Scalp
Thalamus
Young Adult

Keywords

  • Adult
  • Brain
  • Delta Rhythm
  • Electroencephalography
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Polysomnography
  • Positron-Emission Tomography
  • Prefrontal Cortex
  • Sleep
  • Thalamus
  • Wakefulness

Cite this

Dang-Vu, T. T., Desseilles, M., Laureys, S., Degueldre, C., Perrin, F., Phillips, C., ... Peigneux, P. (2005). Cerebral correlates of delta waves during non-REM sleep revisited. NeuroImage, 28(1), 14-21. https://doi.org/10.1016/j.neuroimage.2005.05.028
Dang-Vu, Thien Thanh ; Desseilles, Martin ; Laureys, Steven ; Degueldre, Christian ; Perrin, Fabien ; Phillips, Christophe ; Maquet, Pierre ; Peigneux, Philippe. / Cerebral correlates of delta waves during non-REM sleep revisited. In: NeuroImage. 2005 ; Vol. 28, No. 1. pp. 14-21.
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Dang-Vu, TT, Desseilles, M, Laureys, S, Degueldre, C, Perrin, F, Phillips, C, Maquet, P & Peigneux, P 2005, 'Cerebral correlates of delta waves during non-REM sleep revisited', NeuroImage, vol. 28, no. 1, pp. 14-21. https://doi.org/10.1016/j.neuroimage.2005.05.028

Cerebral correlates of delta waves during non-REM sleep revisited. / Dang-Vu, Thien Thanh; Desseilles, Martin; Laureys, Steven; Degueldre, Christian; Perrin, Fabien; Phillips, Christophe; Maquet, Pierre; Peigneux, Philippe.

In: NeuroImage, Vol. 28, No. 1, 15.10.2005, p. 14-21.

Research output: Contribution to journalArticle

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T1 - Cerebral correlates of delta waves during non-REM sleep revisited

AU - Dang-Vu, Thien Thanh

AU - Desseilles, Martin

AU - Laureys, Steven

AU - Degueldre, Christian

AU - Perrin, Fabien

AU - Phillips, Christophe

AU - Maquet, Pierre

AU - Peigneux, Philippe

PY - 2005/10/15

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N2 - We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement (NREM) sleep in non-sleep-deprived normal young adults, based on the statistical analysis of a positron emission tomography (PET) sleep data set. One hundred fifteen PET scans were obtained using H(2)(15)O under continuous polygraphic monitoring during stages 2-4 of NREM sleep. Correlations between regional cerebral blood flow (rCBF) and delta power (1.5-4 Hz) spectral density were analyzed using statistical parametric mapping (SPM2). Delta power values obtained at central scalp locations negatively correlated during NREM sleep with rCBF in the ventromedial prefrontal cortex, the basal forebrain, the striatum, the anterior insula, and the precuneus. These regions embrace the set of brain areas in which rCBF decreases during slow wave sleep (SWS) as compared to Rapid Eye Movement (REM) sleep and wakefulness (Maquet, P., Degueldre, C., Delfiore, G., Aerts, J., Peters, J.M., Luxen, A., Franck, G., 1997. Functional neuroanatomy of human slow wave sleep. J. Neurosci. 17, 2807-S2812), supporting the notion that delta activity is a valuable prominent feature of NREM sleep. A strong association was observed between rCBF in the ventromedial prefrontal regions and delta power, in agreement with electrophysiological studies. In contrast to the results of a previous PET study investigating the brain correlates of delta activity (Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A.C., Jones, B.E., 1997. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J. Neurosci. 17, 4800-4808), in which waking scans were mixed with NREM sleep scans, no correlation was found with thalamus activity. This latter result stresses the importance of an extra-thalamic delta rhythm among the synchronous NREM sleep oscillations. Consequently, this rCBF distribution might preferentially reflect a particular modulation of the cellular processes involved in the generation of cortical delta waves during NREM sleep.

AB - We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement (NREM) sleep in non-sleep-deprived normal young adults, based on the statistical analysis of a positron emission tomography (PET) sleep data set. One hundred fifteen PET scans were obtained using H(2)(15)O under continuous polygraphic monitoring during stages 2-4 of NREM sleep. Correlations between regional cerebral blood flow (rCBF) and delta power (1.5-4 Hz) spectral density were analyzed using statistical parametric mapping (SPM2). Delta power values obtained at central scalp locations negatively correlated during NREM sleep with rCBF in the ventromedial prefrontal cortex, the basal forebrain, the striatum, the anterior insula, and the precuneus. These regions embrace the set of brain areas in which rCBF decreases during slow wave sleep (SWS) as compared to Rapid Eye Movement (REM) sleep and wakefulness (Maquet, P., Degueldre, C., Delfiore, G., Aerts, J., Peters, J.M., Luxen, A., Franck, G., 1997. Functional neuroanatomy of human slow wave sleep. J. Neurosci. 17, 2807-S2812), supporting the notion that delta activity is a valuable prominent feature of NREM sleep. A strong association was observed between rCBF in the ventromedial prefrontal regions and delta power, in agreement with electrophysiological studies. In contrast to the results of a previous PET study investigating the brain correlates of delta activity (Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A.C., Jones, B.E., 1997. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J. Neurosci. 17, 4800-4808), in which waking scans were mixed with NREM sleep scans, no correlation was found with thalamus activity. This latter result stresses the importance of an extra-thalamic delta rhythm among the synchronous NREM sleep oscillations. Consequently, this rCBF distribution might preferentially reflect a particular modulation of the cellular processes involved in the generation of cortical delta waves during NREM sleep.

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KW - Brain

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KW - Electroencephalography

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Male

KW - Polysomnography

KW - Positron-Emission Tomography

KW - Prefrontal Cortex

KW - Sleep

KW - Thalamus

KW - Wakefulness

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DO - 10.1016/j.neuroimage.2005.05.028

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JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 1

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Dang-Vu TT, Desseilles M, Laureys S, Degueldre C, Perrin F, Phillips C et al. Cerebral correlates of delta waves during non-REM sleep revisited. NeuroImage. 2005 Oct 15;28(1):14-21. https://doi.org/10.1016/j.neuroimage.2005.05.028