CD5+ B cells from bovine leukemia virus infected cows are activated cycling cells responsive to interleukin 2

J P Matheise, M Delcommenne, A Mager, C H Didembourg, Jean-Jacques Letesson

Research output: Contribution to journalArticle

Abstract

Most of the B cells from bovine leukemia virus (BLV) infected cows in persistent lymphocytosis (PL) were known to express the CD5 T-cell marker but it was not known whether this peculiar membrane phenotype relates to an activation state. It was demonstrated that these B cells were also flagged by two other membrane markers normally borne by cells belonging to the myeloid lineage (namely CD11b and CD11c). Moreover, cell cycle analysis illustrated that a significant percentage of these B cells (greater than 15%) left their resting (G0/G1) status and progressed through the cell cycle. In addition, T-cell-depleted peripheral blood mononuclear cells from animals in PL were shown to proliferate in response to a IL-2-containing supernatant (MLA 144). These results indicate that the CD5+ B cells from BLV-infected cows in PL are activated cells.
Original languageEnglish
Pages (from-to)304-9
Number of pages6
JournalLeukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Volume6
Issue number4
Publication statusPublished - 1992

Fingerprint

Bovine Leukemia Virus
B-Cell Leukemia
Lymphocytosis
Interleukin-2
Cell Cycle
B-Lymphocytes
T-Lymphocytes
Membranes
Blood Cells
Phenotype

Cite this

@article{550234bb5993417eac19ce6e3c22e779,
title = "CD5+ B cells from bovine leukemia virus infected cows are activated cycling cells responsive to interleukin 2",
abstract = "Most of the B cells from bovine leukemia virus (BLV) infected cows in persistent lymphocytosis (PL) were known to express the CD5 T-cell marker but it was not known whether this peculiar membrane phenotype relates to an activation state. It was demonstrated that these B cells were also flagged by two other membrane markers normally borne by cells belonging to the myeloid lineage (namely CD11b and CD11c). Moreover, cell cycle analysis illustrated that a significant percentage of these B cells (greater than 15{\%}) left their resting (G0/G1) status and progressed through the cell cycle. In addition, T-cell-depleted peripheral blood mononuclear cells from animals in PL were shown to proliferate in response to a IL-2-containing supernatant (MLA 144). These results indicate that the CD5+ B cells from BLV-infected cows in PL are activated cells.",
author = "Matheise, {J P} and M Delcommenne and A Mager and Didembourg, {C H} and Jean-Jacques Letesson",
year = "1992",
language = "English",
volume = "6",
pages = "304--9",
journal = "Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - CD5+ B cells from bovine leukemia virus infected cows are activated cycling cells responsive to interleukin 2

AU - Matheise, J P

AU - Delcommenne, M

AU - Mager, A

AU - Didembourg, C H

AU - Letesson, Jean-Jacques

PY - 1992

Y1 - 1992

N2 - Most of the B cells from bovine leukemia virus (BLV) infected cows in persistent lymphocytosis (PL) were known to express the CD5 T-cell marker but it was not known whether this peculiar membrane phenotype relates to an activation state. It was demonstrated that these B cells were also flagged by two other membrane markers normally borne by cells belonging to the myeloid lineage (namely CD11b and CD11c). Moreover, cell cycle analysis illustrated that a significant percentage of these B cells (greater than 15%) left their resting (G0/G1) status and progressed through the cell cycle. In addition, T-cell-depleted peripheral blood mononuclear cells from animals in PL were shown to proliferate in response to a IL-2-containing supernatant (MLA 144). These results indicate that the CD5+ B cells from BLV-infected cows in PL are activated cells.

AB - Most of the B cells from bovine leukemia virus (BLV) infected cows in persistent lymphocytosis (PL) were known to express the CD5 T-cell marker but it was not known whether this peculiar membrane phenotype relates to an activation state. It was demonstrated that these B cells were also flagged by two other membrane markers normally borne by cells belonging to the myeloid lineage (namely CD11b and CD11c). Moreover, cell cycle analysis illustrated that a significant percentage of these B cells (greater than 15%) left their resting (G0/G1) status and progressed through the cell cycle. In addition, T-cell-depleted peripheral blood mononuclear cells from animals in PL were shown to proliferate in response to a IL-2-containing supernatant (MLA 144). These results indicate that the CD5+ B cells from BLV-infected cows in PL are activated cells.

M3 - Article

C2 - 1375303

VL - 6

SP - 304

EP - 309

JO - Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K

JF - Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K

SN - 0887-6924

IS - 4

ER -