Abstract

Stress response to fluctuating environments often implies a time-consuming reprogramming of gene expression. In bacteria, the so-called bet hedging strategy, which promotes phenotypic stochasticity within a cell population, is the only fast stress response described so far 1. Here, we show that Caulobacter crescentus asymmetrical cell division allows an immediate bimodal response to a toxic metals-rich environment by allocating specific defence strategies to morphologically and functionally distinct siblings. In this context, a motile swarmer cell favours negative chemotaxis to flee from a copper source, whereas a sessile stalked sibling engages a ready-to-use PcoAB copper homeostasis system, providing evidence of a prompt stress response through intrinsic bacterial dimorphism.

Original languageEnglish
Article number16098
JournalNature Microbiology
Volume1
Issue number9
DOIs
Publication statusPublished - 4 Jul 2016

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Caulobacter crescentus
Copper
Poisons
Chemotaxis
Cell Division
Homeostasis
Metals
Bacteria
Gene Expression
Population

Cite this

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title = "Caulobacter crescentus intrinsic dimorphism provides a prompt bimodal response to copper stress",
abstract = "Stress response to fluctuating environments often implies a time-consuming reprogramming of gene expression. In bacteria, the so-called bet hedging strategy, which promotes phenotypic stochasticity within a cell population, is the only fast stress response described so far 1. Here, we show that Caulobacter crescentus asymmetrical cell division allows an immediate bimodal response to a toxic metals-rich environment by allocating specific defence strategies to morphologically and functionally distinct siblings. In this context, a motile swarmer cell favours negative chemotaxis to flee from a copper source, whereas a sessile stalked sibling engages a ready-to-use PcoAB copper homeostasis system, providing evidence of a prompt stress response through intrinsic bacterial dimorphism.",
author = "{\'E}meline Lawaree and S{\'e}bastien Gillet and Gwenna{\"e}lle Louis and Fran{\cc}oise Tilquin and {Le Blastier}, Sophie and Pierre Cambier and Jean-Yves Matroule",
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AU - Lawaree, Émeline

AU - Gillet, Sébastien

AU - Louis, Gwennaëlle

AU - Tilquin, Françoise

AU - Le Blastier, Sophie

AU - Cambier, Pierre

AU - Matroule, Jean-Yves

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