Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017

Estelle Hess, Francesco Renzi, Panu Karhunen, Mélanie Dol, Adrien Lefevre, Jenny Antikainen, Elodie Carlier, Johanna Hästbacka, Guy Cornelis

Research output: Contribution to journalArticle

Abstract

We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000–2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A–C) caused most (91.8%) human infections, despite constituting only 7.6% of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A–C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans.
Original languageEnglish
Pages (from-to)2195-2201
Number of pages7
JournalEmerging Infectious Diseases
Volume24
Issue number12
DOIs
Publication statusPublished - 25 Oct 2018

Fingerprint

Capnocytophaga
District Hospitals
Finland
Dogs
Immune System Diseases
Bites and Stings
Infection
Serogroup
Alcoholism
Virulence
Western Blotting
Smoking
Polymerase Chain Reaction

Keywords

  • 16S rDNA sequencing
  • Capnocytophaga canimorsus
  • Finland
  • Helsinki
  • Helsinki Hospital District
  • bacteria
  • capsular serovar
  • capsular typing
  • coagulopathy
  • disease severity
  • dog commensal
  • dogs
  • human infection
  • sepsis
  • septic shock
  • serovar J
  • serovar K
  • typing
  • virulence
  • zoonoses

Cite this

@article{a3d34428a4fd4fb39ded42e9b08d20d4,
title = "Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017",
abstract = "We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000–2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A–C) caused most (91.8{\%}) human infections, despite constituting only 7.6{\%} of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A–C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans.",
keywords = "16S rDNA sequencing, Capnocytophaga canimorsus, Finland, Helsinki, Helsinki Hospital District, bacteria, capsular serovar, capsular typing, coagulopathy, disease severity, dog commensal, dogs, human infection, sepsis, septic shock, serovar J, serovar K, typing, virulence, zoonoses",
author = "Estelle Hess and Francesco Renzi and Panu Karhunen and M{\'e}lanie Dol and Adrien Lefevre and Jenny Antikainen and Elodie Carlier and Johanna H{\"a}stbacka and Guy Cornelis",
year = "2018",
month = "10",
day = "25",
doi = "DOI: 10.3201/eid2412.172060",
language = "English",
volume = "24",
pages = "2195--2201",
journal = "Emerging Infectious Diseases",
issn = "1080-6059",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "12",

}

Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017. / Hess, Estelle; Renzi, Francesco; Karhunen, Panu; Dol, Mélanie; Lefevre, Adrien ; Antikainen, Jenny; Carlier, Elodie; Hästbacka, Johanna; Cornelis, Guy.

In: Emerging Infectious Diseases, Vol. 24, No. 12, 25.10.2018, p. 2195-2201.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017

AU - Hess, Estelle

AU - Renzi, Francesco

AU - Karhunen, Panu

AU - Dol, Mélanie

AU - Lefevre, Adrien

AU - Antikainen, Jenny

AU - Carlier, Elodie

AU - Hästbacka, Johanna

AU - Cornelis, Guy

PY - 2018/10/25

Y1 - 2018/10/25

N2 - We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000–2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A–C) caused most (91.8%) human infections, despite constituting only 7.6% of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A–C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans.

AB - We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000–2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A–C) caused most (91.8%) human infections, despite constituting only 7.6% of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A–C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans.

KW - 16S rDNA sequencing

KW - Capnocytophaga canimorsus

KW - Finland

KW - Helsinki

KW - Helsinki Hospital District

KW - bacteria

KW - capsular serovar

KW - capsular typing

KW - coagulopathy

KW - disease severity

KW - dog commensal

KW - dogs

KW - human infection

KW - sepsis

KW - septic shock

KW - serovar J

KW - serovar K

KW - typing

KW - virulence

KW - zoonoses

UR - https://wwwnc.cdc.gov/eid/article/24/12/17-2060_article

UR - http://www.scopus.com/inward/record.url?scp=85056712113&partnerID=8YFLogxK

U2 - DOI: 10.3201/eid2412.172060

DO - DOI: 10.3201/eid2412.172060

M3 - Article

VL - 24

SP - 2195

EP - 2201

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6059

IS - 12

ER -