Projects per year
Abstract
Titanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC nanoparticles (NPs).
ObjectiveTo study the toxicodynamics and toxicokinetics of TiC NPs in Sprague Dawley rats in acute (24 h) and subacute (28 days) oral administrations. The acute doses were 0.5, 5, 50, 300 and 1000 mg kg−1; the subacute doses were 0.5 and 50 mg kg−1.
ResultsOrgan histopathological examination (esophagus, stomach, intestines, spleen, liver, and kidneys) indicates the absence of damage at all applied doses, in both assessments. In the acute administration, alkaline phosphatases increased (5, 300 and 1000 mg kg−1), ASAT increased (1000 mg kg−1) and bile salts decreased (0.5 mg kg−1). No alterations in urine parameters (sodium, potassium, osmolarity) were found. Acute administration of TiC caused mineral changes in organs (liver, spleen, kidneys). TiC was mostly cleared by feces excretion 24 h after administration, in subacute administration causing variations in mineral absorption (Mg, Al, P, S, Ca, Zn). TiC could pass the intestinal barrier as TiC traces were detected in urine.
ConclusionNo sign of toxicity was found after oral administration. TiC was excreted mostly in feces producing mineral absorption alterations. Low traces were retrieved in urine, indicating that TiC can cross the intestinal barrier.
Original language | English |
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Pages (from-to) | 172-187 |
Number of pages | 16 |
Journal | Toxicology Reports |
Volume | 1 |
Early online date | 12 May 2014 |
DOIs | |
Publication status | Published - 12 May 2014 |
Keywords
- Biodistribution
- Histopathology
- PIXE
- Plasma
- Titanium carbide nanoparticle
- Toxicity
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Dive into the research topics of 'Can TiC nanoparticles produce toxicity in oral administration to rats?'. Together they form a unique fingerprint.Projects
- 1 Finished
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NANOTOXICO: In vitro and in vivo toxicological study of three types of nanoparticles od economic interest in the walloon region
Lucas, S. (PI), Masereel, B. (PI), TOUSSAINT, O. (PI), BELOT, N. (Researcher), BOTMAN, M.-C. (Researcher), De Glas, V. (Technician), Fattaccioli, A. (Technician), Fransolet, M. (Technician), FRIPPIAT, C. (Researcher), GALLOY, C. (Researcher), JACQUES, D. (Researcher), LAMBINON, F. (Technician), LESCRENIER, M. (Technician), MARIJSSE, J. (Researcher), NOEL, F. (Technician), Piret, J.-P. (Researcher), ROLIN, S. (Researcher), Saout, C. (Researcher), VANKONINGSLOO, S. (Researcher), Hespel, B. (CoI), Leonis, J.-P. (Support role), LOZANO GARCIA, O. (Researcher), Alpan, L. (Technician) & Laloy, J. (Researcher)
1/01/06 → 31/12/11
Project: Research
Equipment
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Electron Microscopy
Colomer, J.-F. (Manager) & Charlier, C. (Operator)
Technological Platform Morphology - ImagingFacility/equipment: Equipment
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Histology platform
Nicaise, C. (Manager), Poumay, Y. (Manager) & Bielarz, V. (Other)
Technological Platform Morphology - ImagingFacility/equipment: Equipment
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Synthesis, Irradiation and Analysis of Materials (SIAM)
Louette, P. (Manager), Colaux, J. (Manager), Felten, A. (Manager), Tabarrant, T. (Operator), COME, F. (Operator) & Debarsy, P.-L. (Manager)
Technological Platform Synthesis, Irradiation and Analysis of MaterialsFacility/equipment: Technological Platform