Abstract

Background

Titanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC nanoparticles (NPs).

Objective

To study the toxicodynamics and toxicokinetics of TiC NPs in Sprague Dawley rats in acute (24 h) and subacute (28 days) oral administrations. The acute doses were 0.5, 5, 50, 300 and 1000 mg kg−1; the subacute doses were 0.5 and 50 mg kg−1.

Results

Organ histopathological examination (esophagus, stomach, intestines, spleen, liver, and kidneys) indicates the absence of damage at all applied doses, in both assessments. In the acute administration, alkaline phosphatases increased (5, 300 and 1000 mg kg−1), ASAT increased (1000 mg kg−1) and bile salts decreased (0.5 mg kg−1). No alterations in urine parameters (sodium, potassium, osmolarity) were found. Acute administration of TiC caused mineral changes in organs (liver, spleen, kidneys). TiC was mostly cleared by feces excretion 24 h after administration, in subacute administration causing variations in mineral absorption (Mg, Al, P, S, Ca, Zn). TiC could pass the intestinal barrier as TiC traces were detected in urine.

Conclusion

No sign of toxicity was found after oral administration. TiC was excreted mostly in feces producing mineral absorption alterations. Low traces were retrieved in urine, indicating that TiC can cross the intestinal barrier.

Original languageEnglish
Pages (from-to)172-187
Number of pages16
JournalToxicology Reports
Volume1
Early online date12 May 2014
DOIs
Publication statusPublished - 12 May 2014

Fingerprint

Nanoparticles
Minerals
Oral Administration
Toxicity
Rats
Urine
Feces
Spleen
Kidney
Nanostructures
Liver
Ceramics
Bile Acids and Salts
Osmolar Concentration
Toxicology
Esophagus
Intestines
Alkaline Phosphatase
Sprague Dawley Rats
Stomach

Keywords

  • Biodistribution
  • Histopathology
  • PIXE
  • Plasma
  • Titanium carbide nanoparticle
  • Toxicity

Cite this

@article{a5948390d2b54dca9804340274ac4233,
title = "Can TiC nanoparticles produce toxicity in oral administration to rats?",
abstract = "BackgroundTitanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC nanoparticles (NPs).ObjectiveTo study the toxicodynamics and toxicokinetics of TiC NPs in Sprague Dawley rats in acute (24 h) and subacute (28 days) oral administrations. The acute doses were 0.5, 5, 50, 300 and 1000 mg kg−1; the subacute doses were 0.5 and 50 mg kg−1.ResultsOrgan histopathological examination (esophagus, stomach, intestines, spleen, liver, and kidneys) indicates the absence of damage at all applied doses, in both assessments. In the acute administration, alkaline phosphatases increased (5, 300 and 1000 mg kg−1), ASAT increased (1000 mg kg−1) and bile salts decreased (0.5 mg kg−1). No alterations in urine parameters (sodium, potassium, osmolarity) were found. Acute administration of TiC caused mineral changes in organs (liver, spleen, kidneys). TiC was mostly cleared by feces excretion 24 h after administration, in subacute administration causing variations in mineral absorption (Mg, Al, P, S, Ca, Zn). TiC could pass the intestinal barrier as TiC traces were detected in urine.ConclusionNo sign of toxicity was found after oral administration. TiC was excreted mostly in feces producing mineral absorption alterations. Low traces were retrieved in urine, indicating that TiC can cross the intestinal barrier.",
keywords = "Biodistribution, Histopathology, PIXE, Plasma, Titanium carbide nanoparticle, Toxicity",
author = "Julie Laloy and {Lozano Garcia}, Omar and Lutfiye Alpan and {Mejia Mendoza}, {Jorge Humberto} and Olivier Toussaint and Bernard Masereel and Jean-Michel Dogne and St{\'e}phane Lucas",
year = "2014",
month = "5",
day = "12",
doi = "10.1016/j.toxrep.2014.03.004",
language = "English",
volume = "1",
pages = "172--187",
journal = "Toxicology Reports",
issn = "2214-7500",
publisher = "Elsevier Scientific Publishers Ireland",

}

TY - JOUR

T1 - Can TiC nanoparticles produce toxicity in oral administration to rats?

AU - Laloy, Julie

AU - Lozano Garcia, Omar

AU - Alpan, Lutfiye

AU - Mejia Mendoza, Jorge Humberto

AU - Toussaint, Olivier

AU - Masereel, Bernard

AU - Dogne, Jean-Michel

AU - Lucas, Stéphane

PY - 2014/5/12

Y1 - 2014/5/12

N2 - BackgroundTitanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC nanoparticles (NPs).ObjectiveTo study the toxicodynamics and toxicokinetics of TiC NPs in Sprague Dawley rats in acute (24 h) and subacute (28 days) oral administrations. The acute doses were 0.5, 5, 50, 300 and 1000 mg kg−1; the subacute doses were 0.5 and 50 mg kg−1.ResultsOrgan histopathological examination (esophagus, stomach, intestines, spleen, liver, and kidneys) indicates the absence of damage at all applied doses, in both assessments. In the acute administration, alkaline phosphatases increased (5, 300 and 1000 mg kg−1), ASAT increased (1000 mg kg−1) and bile salts decreased (0.5 mg kg−1). No alterations in urine parameters (sodium, potassium, osmolarity) were found. Acute administration of TiC caused mineral changes in organs (liver, spleen, kidneys). TiC was mostly cleared by feces excretion 24 h after administration, in subacute administration causing variations in mineral absorption (Mg, Al, P, S, Ca, Zn). TiC could pass the intestinal barrier as TiC traces were detected in urine.ConclusionNo sign of toxicity was found after oral administration. TiC was excreted mostly in feces producing mineral absorption alterations. Low traces were retrieved in urine, indicating that TiC can cross the intestinal barrier.

AB - BackgroundTitanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC nanoparticles (NPs).ObjectiveTo study the toxicodynamics and toxicokinetics of TiC NPs in Sprague Dawley rats in acute (24 h) and subacute (28 days) oral administrations. The acute doses were 0.5, 5, 50, 300 and 1000 mg kg−1; the subacute doses were 0.5 and 50 mg kg−1.ResultsOrgan histopathological examination (esophagus, stomach, intestines, spleen, liver, and kidneys) indicates the absence of damage at all applied doses, in both assessments. In the acute administration, alkaline phosphatases increased (5, 300 and 1000 mg kg−1), ASAT increased (1000 mg kg−1) and bile salts decreased (0.5 mg kg−1). No alterations in urine parameters (sodium, potassium, osmolarity) were found. Acute administration of TiC caused mineral changes in organs (liver, spleen, kidneys). TiC was mostly cleared by feces excretion 24 h after administration, in subacute administration causing variations in mineral absorption (Mg, Al, P, S, Ca, Zn). TiC could pass the intestinal barrier as TiC traces were detected in urine.ConclusionNo sign of toxicity was found after oral administration. TiC was excreted mostly in feces producing mineral absorption alterations. Low traces were retrieved in urine, indicating that TiC can cross the intestinal barrier.

KW - Biodistribution

KW - Histopathology

KW - PIXE

KW - Plasma

KW - Titanium carbide nanoparticle

KW - Toxicity

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U2 - 10.1016/j.toxrep.2014.03.004

DO - 10.1016/j.toxrep.2014.03.004

M3 - Article

VL - 1

SP - 172

EP - 187

JO - Toxicology Reports

JF - Toxicology Reports

SN - 2214-7500

ER -