Calcium Carbonate Nanoplate Assemblies with Directed High-Energy Facets: Additive-Free Synthesis, High Drug Loading, and Sustainable Releasing

Jing Zhang, Yu Li, Hao Xie, Bao Lian Su, Bin Yao, Yixia Yin, Shipu Li, Fang Chen, Zhengyi Fu

Research output: Contribution to journalArticlepeer-review

Abstract

Developing drug delivery systems (DDSs) with high drug-loading capacity and sustainable releasing is critical for long-term chemotherapeutic efficacy, and it still remains challenging. Herein, vaterite CaCO<inf>3</inf> nanoplate assemblies with exposed high-energy {001} facets have been synthesized via a novel, additive-free strategy. The product shows a high doxorubicin-loading capacity (65%); the best of all the CaCO<inf>3</inf>-based DDSs so far. Also, the product's sustainable releasing performance and its inhibition of the initial burst release, together, endow it with long-term drug efficacy. The work may shed light on exposing directed high-energy facets for rationally designing of a drug delivery system with long-term efficacy. (Graph Presented).

Original languageEnglish
Pages (from-to)15686-15691
Number of pages6
JournalACS Applied Materials and Interfaces
Volume7
Issue number29
DOIs
Publication statusPublished - 29 Jul 2015

Keywords

  • additive-free synthesis
  • calcium carbonate
  • drug delivery
  • high-energy facet
  • nanostructure

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