C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Lucas Schoenauen; François-Xavier Stubbe; Dirk Van Gestel; Sébastien Penninckx; Anne-Catherine Heuskin

doi:10.1016/j.ctro.2023.100712

C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Lucas Schoenauen
, François-Xavier Stubbe
, Dirk Van Gestel
, Sébastien Penninckx
, Anne-Catherine Heuskin

Research output: Contribution to journal › Article › peer-review

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Abstract

This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C. elegans suitability as a screening model for studying the LET impact on the FLASH effect, reinforcing its potential in radiation research.

Original language	English
Article number	100712
Pages (from-to)	100712
Journal	Clinical and translational radiation oncology
Volume	45
DOIs	https://doi.org/10.1016/j.ctro.2023.100712
Publication status	Published - Mar 2024

Funding

The authors thank the laboratory of Molecular Genetics (GÉMO) and Damien Hermand from University of Namur for the C. elegans strain and maintenance, and Christophe Vandekerkhove for the technical help during the electron irradiations at Bordet Institute.

Funders
Bordet Institute
University of Namur

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

C. elegans embryo
Electron flash
Proton flash

Access to Document

10.1016/j.ctro.2023.100712

231218_ART_Schoenauen2023Final published version, 486 KBLicence: CC BY

Cite this

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abstract = "This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C. elegans suitability as a screening model for studying the LET impact on the FLASH effect, reinforcing its potential in radiation research. ",

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AU - Heuskin, Anne-Catherine

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KW - Electron flash

KW - Proton flash

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C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Abstract

Funding

UN SDGs

Keywords

Access to Document

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C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Abstract

Funding

UN SDGs

Keywords

Access to Document

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