Both the hippocampus and striatum are involved in consolidation of motor sequence memory

Geneviève Albouy, Virginie Sterpenich, Evelyne Balteau, Gilles Vandewalle, Martin Desseilles, Thanh Dang-Vu, Annabelle Darsaud, Perrine Ruby, Pierre-Hervé Luppi, Christian Degueldre, Philippe Peigneux, André Luxen, Pierre Maquet

Research output: Contribution to journalArticlepeer-review

Abstract

Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.
Original languageEnglish
Pages (from-to)261-72
Number of pages12
JournalNeuron
Volume58
Issue number2
DOIs
Publication statusPublished - 24 Apr 2008

Keywords

  • Adult
  • Analysis of Variance
  • Brain Mapping
  • Corpus Striatum
  • Eye Movements
  • Female
  • Hippocampus
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Oxygen
  • Reaction Time
  • Serial Learning
  • Task Performance and Analysis

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