Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

Stéphane P. Vincent; Kévin Buffet; Iwona Nierengarten; Anne Imberty; Jean François Nierengarten

doi:10.1002/chem.201504110

Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

Stéphane P. Vincent, Kévin Buffet, Iwona Nierengarten, Anne Imberty, Jean François Nierengarten

Unit of organic chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self-assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa.

Original language	English
Pages (from-to)	88-92
Number of pages	5
Journal	Chemistry: A European Journal
Volume	22
Issue number	1
DOIs	https://doi.org/10.1002/chem.201504110
Publication status	Published - 4 Jan 2016

Keywords

click chemistry
glycoclusters
lectin
pillar[5]arenes
rotaxane

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10.1002/chem.201504110

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abstract = "A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self-assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa.",

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AU - Imberty, Anne

AU - Nierengarten, Jean François

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KW - pillar[5]arenes

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Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

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Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

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