Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

Stéphane P. Vincent, Kévin Buffet, Iwona Nierengarten, Anne Imberty, Jean François Nierengarten

Research output: Contribution to journalArticle

Abstract

A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self-assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalChemistry: A European Journal
Volume22
Issue number1
DOIs
Publication statusPublished - 4 Jan 2016

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Keywords

  • click chemistry
  • glycoclusters
  • lectin
  • pillar[5]arenes
  • rotaxane

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