Abstract
Substituted (thio)hydantoins (2-thioxoimidazolidinones and imidazolidinediones) were reported as new potential reversible inhibitors of fatty acid amide hydrolase (FAAH). Their binding mode to FAAH was explored to rationalize their activity and give idea to design highly active inhibitors. Starting from the crystal structure of one of these molecules, docking studies provide us with rational basis for the design of new inhibitors within the thiohydantoin family.
Original language | English |
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Pages (from-to) | 4772-4776 |
Number of pages | 5 |
Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 16 |
Issue number | 18 |
DOIs | |
Publication status | Published - 15 Sept 2006 |
Keywords
- (thio)Hydantoin
- Binding mode
- Crystallography
- FAAH
- Molecular modeling
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CCDC 606773: Experimental Crystal Structure Determination
Lambert, D. M. (Contributor), Michaux, C. (Contributor), Muccioli, G. (Contributor) & Wouters, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2007
DOI: 10.5517/ccncdbq, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccncdbq&sid=DataCite
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