Auxin activity and molecular structure of 2-alkylindole-3-acetic acids

Snjezana Antolic, Eduard Dolusic, Erika K. Kozic, Biserka Kojic-Prodic, Volker Magnus, Michael Ramek, Sanja Tomic

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2-Methylindole-3-acetic acid (2-Me-IAA) is a known auxin, but its 2-ethyl homologue has been considered inactive. Here we show that the compound previously bioassayed as '2-ethylindole-3-acetic acid' (2-Et-IAA) was, in fact, 3-(3-methylindol-2-yl)propionic acid. The proper 2-Et-IAA and its 2-(n-propyl) homologue (2-Pr-IAA) are prepared, unambiguously characterized, and their auxin activity is demonstrated in the Avena coleoptile-section straight-growth test. Their half-optimal concentrations are approximately the same as for 2-Me-IAA ...
Original languageEnglish
Pages (from-to)235-252
Number of pages18
JournalPlant Growth Regulation
Issue number3
Publication statusPublished - 2003


  • Conformational analysis
  • 2-Ethylindole-3-acetic acid
  • Indole-3 acetic acid
  • Auxin
  • X-ray crystallography
  • 2-Propylindole-3-acetic acid


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