Asymmetric synthesis of cyclopropane-1,1-dicarboxylates from a -γ- Alkoxy-alkylidenemalonate

A. Krief, L. Provins, A. Froidbise

Research output: Contribution to journalArticlepeer-review

Abstract

2-Metallo-2-sulfonylpropanes and 2-metallo-2-nitropropanes react with the dimethyl alkylidenemalonate derived from the acetonide of D- glyceraldehyde to produce the Michael adduct or the corresponding dimethyl cyclopropane-1,1-dicarboxylate. The nature of the product formed and the relative configuration of the cyclopropane derivative depends upon the nature of the leaving group and the conditions used (solvent and counter ion).
Original languageEnglish
Pages (from-to)1936-1938
Number of pages3
JournalSynlett
Issue number12
Publication statusPublished - 1 Jan 1999

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