Abstract

The evolution of the particle size distribution and the surface composition of silicon carbide and titanium carbide nanoparticle (NP) dispersions were studied. The pre-dispersions were prepared using two commonly used protocols for dispersion: stirring and sonication. Two dispersants were investigated (water and Pluronic F108 1 %) at two stages: predispersion and during in vitro assays. Our data show that for each tested condition, different time-dependent results for the surface chemical composition as well as size and percentage of the agglomerates and the primary particles are observed. De-agglomeration and successive or simultaneous cleaning-wrapping cycles of the nanomaterial are observed and are related to the dispersion method and the medium as well as to the chemical stability of the NP surface. Biological response during in vitro assessment was also performed for one given pre-dispersion time condition and demonstrates that the preparation method significantly alters the results. © 2012 Springer Science+Business Media B.V.
Original languageEnglish
Pages (from-to)815-832
JournalJournal of Nanoparticle Research
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Jan 2012

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toxicology
Toxicology
Sonication
stirring
Dispersions
evaluation
Evaluation
Nanoparticles
Poloxamer
titanium carbides
nanoparticles
Titanium carbide
Chemical stability
agglomeration
particle size distribution
Nanostructured materials
Silicon carbide
Surface structure
Particle size analysis
silicon carbides

Cite this

@article{ef833b302c854355bddb5d36b730fced,
title = "Are stirring and sonication pre-dispersion methods equivalent for in vitro toxicology evaluation of SiC and TiC?",
abstract = "The evolution of the particle size distribution and the surface composition of silicon carbide and titanium carbide nanoparticle (NP) dispersions were studied. The pre-dispersions were prepared using two commonly used protocols for dispersion: stirring and sonication. Two dispersants were investigated (water and Pluronic F108 1 {\%}) at two stages: predispersion and during in vitro assays. Our data show that for each tested condition, different time-dependent results for the surface chemical composition as well as size and percentage of the agglomerates and the primary particles are observed. De-agglomeration and successive or simultaneous cleaning-wrapping cycles of the nanomaterial are observed and are related to the dispersion method and the medium as well as to the chemical stability of the NP surface. Biological response during in vitro assessment was also performed for one given pre-dispersion time condition and demonstrates that the preparation method significantly alters the results. {\circledC} 2012 Springer Science+Business Media B.V.",
author = "{Mejia Mendoza}, {Jorge Humberto} and Vanessa Valembois and Jean-Pascal Piret and Frans Tichelaar and {van Huis}, Marijn and Bernard Masereel and Olivier Toussaint and Joseph Delhalle and Zineb Mekhalif and St{\'e}phane Lucas",
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doi = "10.1007/s11051-012-0815-7",
language = "English",
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TY - JOUR

T1 - Are stirring and sonication pre-dispersion methods equivalent for in vitro toxicology evaluation of SiC and TiC?

AU - Mejia Mendoza, Jorge Humberto

AU - Valembois, Vanessa

AU - Piret, Jean-Pascal

AU - Tichelaar, Frans

AU - van Huis, Marijn

AU - Masereel, Bernard

AU - Toussaint, Olivier

AU - Delhalle, Joseph

AU - Mekhalif, Zineb

AU - Lucas, Stéphane

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The evolution of the particle size distribution and the surface composition of silicon carbide and titanium carbide nanoparticle (NP) dispersions were studied. The pre-dispersions were prepared using two commonly used protocols for dispersion: stirring and sonication. Two dispersants were investigated (water and Pluronic F108 1 %) at two stages: predispersion and during in vitro assays. Our data show that for each tested condition, different time-dependent results for the surface chemical composition as well as size and percentage of the agglomerates and the primary particles are observed. De-agglomeration and successive or simultaneous cleaning-wrapping cycles of the nanomaterial are observed and are related to the dispersion method and the medium as well as to the chemical stability of the NP surface. Biological response during in vitro assessment was also performed for one given pre-dispersion time condition and demonstrates that the preparation method significantly alters the results. © 2012 Springer Science+Business Media B.V.

AB - The evolution of the particle size distribution and the surface composition of silicon carbide and titanium carbide nanoparticle (NP) dispersions were studied. The pre-dispersions were prepared using two commonly used protocols for dispersion: stirring and sonication. Two dispersants were investigated (water and Pluronic F108 1 %) at two stages: predispersion and during in vitro assays. Our data show that for each tested condition, different time-dependent results for the surface chemical composition as well as size and percentage of the agglomerates and the primary particles are observed. De-agglomeration and successive or simultaneous cleaning-wrapping cycles of the nanomaterial are observed and are related to the dispersion method and the medium as well as to the chemical stability of the NP surface. Biological response during in vitro assessment was also performed for one given pre-dispersion time condition and demonstrates that the preparation method significantly alters the results. © 2012 Springer Science+Business Media B.V.

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DO - 10.1007/s11051-012-0815-7

M3 - Article

VL - 14

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EP - 832

JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

SN - 1388-0764

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