Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics

Olivier Toussaint, José Remacle, Jean François Dierick, Thierry Pascal, Christophe Frippiat, Véronique Royer, Florence Chainiaux

Research output: Contribution to journalArticle

Abstract

B. L. Strehler wrote that "Any system that is not in thermodynamic equilibrium will approach that state at a rate that is a function of absolute temperature and the energy barriers to the rearrangements of components". Far-from-equilibrium thermodynamics allows a global systemic description of the cellular behaviour. This approach transcends the genetic and stochastic considerations on ageing as well as some evolutionary questions about ageing. The fundamental difference between the processes of development and ageing could reflect the intrinsic differences existing between biological systems where an increase in specific entropy production (SEP) is, respectively, still possible or not. The increase of the potential of SEP which probably occurred with evolution might explain in part why life span could increase. However, this SEP-driven increase in life span was possible only in those species which did not take advantage of their increased potential of SEP to ameliorate their reproductive capacity at the expense of possible increases in repair capacity. The criteria of stability of far-from-equilibrium open systems and the theory of attractors also help to sort the possible types of cellular stress responses: normal ageing, hormesis, stress-induced premature senescence, apoptosis or necrosis. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)937-946
Number of pages10
JournalMechanisms of Ageing and Development
Volume123
Issue number8
DOIs
Publication statusPublished - 30 Apr 2002

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Hormesis
Entropy
Thermodynamics
Aging of materials
Phenotype
Energy barriers
Open systems
Biological systems
Ireland
Repair
Necrosis
Apoptosis
Temperature

Keywords

  • Ageing
  • Attractor
  • Fibroblast
  • Hormesis
  • Senescence
  • Stress
  • Thermodynamics

Cite this

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abstract = "B. L. Strehler wrote that {"}Any system that is not in thermodynamic equilibrium will approach that state at a rate that is a function of absolute temperature and the energy barriers to the rearrangements of components{"}. Far-from-equilibrium thermodynamics allows a global systemic description of the cellular behaviour. This approach transcends the genetic and stochastic considerations on ageing as well as some evolutionary questions about ageing. The fundamental difference between the processes of development and ageing could reflect the intrinsic differences existing between biological systems where an increase in specific entropy production (SEP) is, respectively, still possible or not. The increase of the potential of SEP which probably occurred with evolution might explain in part why life span could increase. However, this SEP-driven increase in life span was possible only in those species which did not take advantage of their increased potential of SEP to ameliorate their reproductive capacity at the expense of possible increases in repair capacity. The criteria of stability of far-from-equilibrium open systems and the theory of attractors also help to sort the possible types of cellular stress responses: normal ageing, hormesis, stress-induced premature senescence, apoptosis or necrosis. {\circledC} 2002 Elsevier Science Ireland Ltd. All rights reserved.",
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AU - Frippiat, Christophe

AU - Royer, Véronique

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