An efficient synthesis of GDP-hexanolamine, a key tool for the purification of fucosyltransferases

Stéphane P. Vincent, Louis N. Gastinel

Research output: Contribution to journalArticle

Abstract

A new efficient synthesis of GDP-hexanolamine from hexanolamine is reported with an overall yield of 71%. The pyrophosphate formation, the key step of this preparation, was achieved through a sequential GMP activation procedure based on polytrifluoroacetylation of GMP followed by activation of the phosphate group by 1-methylimidazole. © 2002 Published by Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1039-1042
Number of pages4
JournalCarbohydrate Research
Volume337
Issue number11
DOIs
Publication statusPublished - 5 Jun 2002

Keywords

  • GDP-hexanolamine
  • Glycosyltransferase
  • Pyrophosphate synthesis

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