Acid-responsive H 2 -releasing Fe nanoparticles for safe and effective cancer therapy

Zhu Kou, Penghe Zhao, Zhihao Wang, Zhaokui Jin, Lihua Chen, Bao Lian Su, Qianjun He

Research output: Contribution to journalArticle

Abstract

Hydrogen therapy is an emerging and promising strategy for treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H 2 ), but is facing a challenge that the H 2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy. Herein, we propose a nanomedicine strategy of imaging-guided tumour-targeted delivery and tumour microenvironment-triggered release of H 2 to address this issue, and develop a kind of biocompatible carboxymethyl cellulose (CMC)-coated/stabilized Fe (Fe@CMC) nanoparticle with photoacoustic imaging (PAI), tumour targeting and acid responsive hydrogen release properties for cancer therapy. The Fe@CMC nanoparticles have demonstrated high intratumoural accumulation capability, high acid responsiveness, excellent PAI performance, selective cancer-killing effect and high bio-safety in vitro and in vivo. Effective inhibition of tumour growth is achieved by intravenous injection of the Fe@CMC nanoparticles, and the selective anti-cancer mechanism of Fe@CMC is discovered to be originated from the energy metabolism homeostasis regulatory function of the released H 2 . The proposed nanomedicine-mediated hydrogen therapy strategy will open a new window for precise, high-efficacy and safe cancer treatment.

Original languageEnglish
Pages (from-to)2759-2765
Number of pages7
JournalJournal Of Materials Chemistry B
Volume7
Issue number17
DOIs
Publication statusPublished - 1 Jan 2019

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Carboxymethylcellulose Sodium
Hydrogen
Tumors
Nanoparticles
Cellulose
Acids
Medical nanotechnology
Photoacoustic effect
Imaging techniques
Oncology
Solubility
Molecules

Cite this

Kou, Zhu ; Zhao, Penghe ; Wang, Zhihao ; Jin, Zhaokui ; Chen, Lihua ; Su, Bao Lian ; He, Qianjun. / Acid-responsive H 2 -releasing Fe nanoparticles for safe and effective cancer therapy. In: Journal Of Materials Chemistry B. 2019 ; Vol. 7, No. 17. pp. 2759-2765.
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Acid-responsive H 2 -releasing Fe nanoparticles for safe and effective cancer therapy. / Kou, Zhu; Zhao, Penghe; Wang, Zhihao; Jin, Zhaokui; Chen, Lihua; Su, Bao Lian; He, Qianjun.

In: Journal Of Materials Chemistry B, Vol. 7, No. 17, 01.01.2019, p. 2759-2765.

Research output: Contribution to journalArticle

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