Absence of SARS-CoV-2 in the effluent of peritoneal dialysis patients

Alexandre Candellier; Anaïs Scohy; Nicolas Gillet; Benoit Muylkens; Johann Morelle; Leïla Belkhir; Damien Coupeau; Michel Jadoul; Éric Goffin

doi:10.1177/0896860820953061

Absence of SARS-CoV-2 in the effluent of peritoneal dialysis patients

Alexandre Candellier, Anaïs Scohy, Nicolas Gillet, Benoit Muylkens, Johann Morelle, Leïla Belkhir, Damien Coupeau, Michel Jadoul, Éric Goffin

University of Namur

Research output: Contribution to journal › Article › peer-review

Abstract

The pandemic of respiratory disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is life-threatening in peritoneal dialysis (PD) patients. In PD patients with systemic viral infections, peritoneal effluent may be theoretically contaminated. We searched for the presence of SARS-CoV-2 genetic material by real-time reverse transcriptase–polymerase chain reaction assays in serial PD effluents of three PD infected patients. Nasopharyngeal swabs obtained at admission showed high viral load in all three patients, whereas none of the PD effluent specimen tested positive, even after dialysate concentration. Those results support at most a very low SARS-CoV-2 dissemination risk by the peritoneal effluent of PD patients. Imposing special disposal procedures, such as the instillation of hypochlorite in the drainage bags to prevent viral spread to health-care workers, are probably not required.

Original language	English
Pages (from-to)	499-503
Number of pages	5
Journal	Peritoneal Dialysis International
Volume	40
Issue number	5
DOIs	https://doi.org/10.1177/0896860820953061
Publication status	Published - 1 Sept 2020

Keywords

COVID-19
peritoneal dialysis
peritoneal effluent
SARS-CoV-2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/0896860820953061

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title = "Absence of SARS-CoV-2 in the effluent of peritoneal dialysis patients",

abstract = "The pandemic of respiratory disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is life-threatening in peritoneal dialysis (PD) patients. In PD patients with systemic viral infections, peritoneal effluent may be theoretically contaminated. We searched for the presence of SARS-CoV-2 genetic material by real-time reverse transcriptase–polymerase chain reaction assays in serial PD effluents of three PD infected patients. Nasopharyngeal swabs obtained at admission showed high viral load in all three patients, whereas none of the PD effluent specimen tested positive, even after dialysate concentration. Those results support at most a very low SARS-CoV-2 dissemination risk by the peritoneal effluent of PD patients. Imposing special disposal procedures, such as the instillation of hypochlorite in the drainage bags to prevent viral spread to health-care workers, are probably not required.",

keywords = "COVID-19, peritoneal dialysis, peritoneal effluent, SARS-CoV-2",

author = "Alexandre Candellier and Ana{\"i}s Scohy and Nicolas Gillet and Benoit Muylkens and Johann Morelle and Le{\"i}la Belkhir and Damien Coupeau and Michel Jadoul and {\'E}ric Goffin",

note = "Funding Information: The authors thank all the medical, nursing, and technical staff from Dialyse extra-hospitali{\`e}re, Cliniques Universitaires Saint-Luc, Brussels. They particularly thank Professor Hector Rodriguez-Villalobos (Cliniques Universitaires Saint-Luc, Brussels, Belgium) for his implication in PCR assays, Professor Antoine Froidure (Division of Pneumology) for his dedicated care of their dialysis patients, and Dr Arnaud Devresse for fruitful discussions. The author(s) received no financial support for the research, authorship, and/or publication of this article. Publisher Copyright: {\textcopyright} The Author(s) 2020.",

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AU - Candellier, Alexandre

AU - Scohy, Anaïs

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AU - Muylkens, Benoit

AU - Morelle, Johann

AU - Belkhir, Leïla

AU - Coupeau, Damien

AU - Jadoul, Michel

AU - Goffin, Éric

N1 - Funding Information: The authors thank all the medical, nursing, and technical staff from Dialyse extra-hospitalière, Cliniques Universitaires Saint-Luc, Brussels. They particularly thank Professor Hector Rodriguez-Villalobos (Cliniques Universitaires Saint-Luc, Brussels, Belgium) for his implication in PCR assays, Professor Antoine Froidure (Division of Pneumology) for his dedicated care of their dialysis patients, and Dr Arnaud Devresse for fruitful discussions. The author(s) received no financial support for the research, authorship, and/or publication of this article. Publisher Copyright: © The Author(s) 2020.

PY - 2020/9/1

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N2 - The pandemic of respiratory disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is life-threatening in peritoneal dialysis (PD) patients. In PD patients with systemic viral infections, peritoneal effluent may be theoretically contaminated. We searched for the presence of SARS-CoV-2 genetic material by real-time reverse transcriptase–polymerase chain reaction assays in serial PD effluents of three PD infected patients. Nasopharyngeal swabs obtained at admission showed high viral load in all three patients, whereas none of the PD effluent specimen tested positive, even after dialysate concentration. Those results support at most a very low SARS-CoV-2 dissemination risk by the peritoneal effluent of PD patients. Imposing special disposal procedures, such as the instillation of hypochlorite in the drainage bags to prevent viral spread to health-care workers, are probably not required.

AB - The pandemic of respiratory disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is life-threatening in peritoneal dialysis (PD) patients. In PD patients with systemic viral infections, peritoneal effluent may be theoretically contaminated. We searched for the presence of SARS-CoV-2 genetic material by real-time reverse transcriptase–polymerase chain reaction assays in serial PD effluents of three PD infected patients. Nasopharyngeal swabs obtained at admission showed high viral load in all three patients, whereas none of the PD effluent specimen tested positive, even after dialysate concentration. Those results support at most a very low SARS-CoV-2 dissemination risk by the peritoneal effluent of PD patients. Imposing special disposal procedures, such as the instillation of hypochlorite in the drainage bags to prevent viral spread to health-care workers, are probably not required.

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Absence of SARS-CoV-2 in the effluent of peritoneal dialysis patients

Abstract

Keywords

UN SDGs

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