A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical

Bram Harmsen, Koen Robeyns, Johan Wouters, Tom Leyssens

Research output: Contribution to journalArticle

Abstract

Different solid state forms of the research chemical fasoracetam, which counters the effects of Alzheimer's disease, have been subjected to a thermal and structural analysis. Single crystals were obtained from solution evaporation and from the melt. Single-crystal X-ray analyses of the crystals show the existence of 2 hydrated and 1 non-hydrated crystalline form of fasoracetam. Under ambient conditions, the hydrate form I is found to be the most stable form, showing a melting point of 57C. This low melting point, combined with possible water losses could cause problems when formulating the hydrated form and impact the storage conditions of the compound.

Original languageEnglish
Pages (from-to)1317-1321
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume106
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • Alzheimer's disease
  • calorimetry (DSC)
  • crystal structure
  • hydrate
  • polymorphism
  • solvent evaporation
  • thermogravimetric analysis

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  • Equipment

  • Datasets

    CCDC 1489556: Experimental Crystal Structure Determination

    Harmsen, B. (Contributor), Leyssens, T. (Contributor), Robeyns, K. (Contributor) & WOUTERS, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2017

    Dataset

    CCDC 1489557: Experimental Crystal Structure Determination

    Harmsen, B. (Contributor), Leyssens, T. (Contributor), Robeyns, K. (Contributor) & WOUTERS, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2017

    Dataset

    CCDC 1489558: Experimental Crystal Structure Determination

    Harmsen, B. (Contributor), Leyssens, T. (Contributor), Robeyns, K. (Contributor) & WOUTERS, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2017

    Dataset

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