A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

O. Malaspinas, A. Turjman, D. Ribeiro de Sousa, G. Garcia-Cardena, Martine Raes, P. T T Nguyen, Y. Zhang, G. Courbebaisse, C. Lelubre, K. Zouaoui Boudjeltia, B. Chopard

Research output: Contribution to journalArticle


We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.

Original languageEnglish
Pages (from-to)68-76
Number of pages9
JournalJournal of Theoretical Biology
Publication statusPublished - 7 Apr 2016



  • Blood-flow
  • Cerebral aneurysm
  • Clotting
  • Lattice Boltzmann
  • Numerical modelling
  • Thrombosis

Cite this

Malaspinas, O., Turjman, A., Ribeiro de Sousa, D., Garcia-Cardena, G., Raes, M., Nguyen, P. T. T., Zhang, Y., Courbebaisse, G., Lelubre, C., Zouaoui Boudjeltia, K., & Chopard, B. (2016). A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. Journal of Theoretical Biology, 394, 68-76. https://doi.org/10.1016/j.jtbi.2015.12.022