A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

O. Malaspinas, A. Turjman, D. Ribeiro de Sousa, G. Garcia-Cardena, Martine Raes, P. T T Nguyen, Y. Zhang, G. Courbebaisse, C. Lelubre, K. Zouaoui Boudjeltia, B. Chopard

Research output: Contribution to journalArticle

Abstract

We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.

LanguageEnglish
Pages68-76
Number of pages9
JournalJournal of Theoretical Biology
Volume394
DOIs
StatePublished - 7 Apr 2016

Fingerprint

Cerebral Aneurysm
aneurysm
Spatio-temporal Model
Intracranial Aneurysm
Thrombosis
Mechanical Phenomena
CFD Simulation
Aneurysm
Numerical models
Computational fluid dynamics
Time Scales
space and time
Model
Experiment
Experiments
Observation
In Vitro Techniques

Keywords

  • Blood-flow
  • Cerebral aneurysm
  • Clotting
  • Lattice Boltzmann
  • Numerical modelling
  • Thrombosis

Cite this

Malaspinas, O., Turjman, A., Ribeiro de Sousa, D., Garcia-Cardena, G., Raes, M., Nguyen, P. T. T., ... Chopard, B. (2016). A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. DOI: 10.1016/j.jtbi.2015.12.022
Malaspinas, O. ; Turjman, A. ; Ribeiro de Sousa, D. ; Garcia-Cardena, G. ; Raes, Martine ; Nguyen, P. T T ; Zhang, Y. ; Courbebaisse, G. ; Lelubre, C. ; Zouaoui Boudjeltia, K. ; Chopard, B./ A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. In: Journal of Theoretical Biology. 2016 ; Vol. 394. pp. 68-76
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Malaspinas, O, Turjman, A, Ribeiro de Sousa, D, Garcia-Cardena, G, Raes, M, Nguyen, PTT, Zhang, Y, Courbebaisse, G, Lelubre, C, Zouaoui Boudjeltia, K & Chopard, B 2016, 'A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms' Journal of Theoretical Biology, vol. 394, pp. 68-76. DOI: 10.1016/j.jtbi.2015.12.022

A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. / Malaspinas, O.; Turjman, A.; Ribeiro de Sousa, D.; Garcia-Cardena, G.; Raes, Martine; Nguyen, P. T T; Zhang, Y.; Courbebaisse, G.; Lelubre, C.; Zouaoui Boudjeltia, K.; Chopard, B.

In: Journal of Theoretical Biology, Vol. 394, 07.04.2016, p. 68-76.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

AU - Malaspinas,O.

AU - Turjman,A.

AU - Ribeiro de Sousa,D.

AU - Garcia-Cardena,G.

AU - Raes,Martine

AU - Nguyen,P. T T

AU - Zhang,Y.

AU - Courbebaisse,G.

AU - Lelubre,C.

AU - Zouaoui Boudjeltia,K.

AU - Chopard,B.

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KW - Blood-flow

KW - Cerebral aneurysm

KW - Clotting

KW - Lattice Boltzmann

KW - Numerical modelling

KW - Thrombosis

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Malaspinas O, Turjman A, Ribeiro de Sousa D, Garcia-Cardena G, Raes M, Nguyen PTT et al. A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. Journal of Theoretical Biology. 2016 Apr 7;394:68-76. Available from, DOI: 10.1016/j.jtbi.2015.12.022