A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules

V Lemau de Talancé; F Bauer; D Hermand; S P Vincent

doi:10.1016/j.bmcl.2011.10.051

A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules

V Lemau de Talancé, F Bauer, D Hermand, S P Vincent

Research output: Contribution to journal › Article › peer-review

Abstract

This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.

Original language	English
Pages (from-to)	7265-7
Number of pages	3
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	21
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2011.10.051
Publication status	Published - 2011

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10.1016/j.bmcl.2011.10.051

Cite this

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title = "A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules",

abstract = "This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.",

author = "{Lemau de Talanc{\'e}}, V and F Bauer and D Hermand and Vincent, {S P}",

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AU - Lemau de Talancé, V

AU - Bauer, F

AU - Hermand, D

AU - Vincent, S P

PY - 2011

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AB - This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.

U2 - 10.1016/j.bmcl.2011.10.051

DO - 10.1016/j.bmcl.2011.10.051

M3 - Article

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VL - 21

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EP - 7267

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

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