A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules

V Lemau de Talancé, F Bauer, D Hermand, S P Vincent

Research output: Contribution to journalArticle

Abstract

This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.
Original languageEnglish
Pages (from-to)7265-7
Number of pages3
JournalBioorganic & Medicinal Chemistry Letters
Volume21
Issue number24
DOIs
Publication statusPublished - 2011

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