A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules

Nicolas Couvrat, Morgane Sanselme, Yohann Cartigny, Frederic De Smet, Sandrine Rome, Luc Aerts, Luc Quéré, Johan Wouters, Gérard Coquerel

Research output: Contribution to journalArticle

Abstract

This article highlights the unusual behavior of brivaracetam (BRV: An active pharmaceutical ingredient against epilepsy), which leads to a unique phase-ranging from clathrate to solvate to cocrystal-formed with an impressive number of apolar guest molecules (any linear alkanes to esters of fatty acids/alcohols, or waxes). Moreover, the investigation of binary systems between linear alkanes and BRV displayed the systematic existence of a syntectic invariant (one solid melts into two nonmiscible liquids) for CnH2n+2 with n > 7.

Original languageEnglish
Pages (from-to)4807-4810
Number of pages4
JournalCrystal Growth and Design
Volume18
Issue number9
DOIs
Publication statusPublished - 5 Sep 2018

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  • Datasets

    CCDC 1572556: Experimental Crystal Structure Determination

    Couvrat, N. (Creator), Sanselme, M. (Creator), Cartigny, Y. (Creator), De Smet, F. (Creator), Rome, S. (Creator), Aerts, L. (Creator), Quéré, L. (Creator), WOUTERS, J. (Contributor) & Coquerel, G. (Creator), University of Namur, 5 Sep 2018

    Dataset

    CCDC 1553038: Experimental Crystal Structure Determination

    Couvrat, N. (Creator), Sanselme, M. (Creator), Cartigny, Y. (Creator), De Smet, F. (Creator), Rome, S. (Creator), Aerts, L. (Creator), Quéré, L. (Creator), WOUTERS, J. (Contributor) & Coquerel, G. (Creator), University of Namur, 5 Sep 2018

    Dataset

    CCDC 1572555: Experimental Crystal Structure Determination

    Couvrat, N. (Creator), Sanselme, M. (Creator), Cartigny, Y. (Creator), De Smet, F. (Creator), Rome, S. (Contributor), Aerts, L. (Creator), Quéré, L. (Creator), WOUTERS, J. (Contributor) & Coquerel, G. (Creator), University of Namur, 5 Sep 2018

    Dataset

    Cite this

    Couvrat, N., Sanselme, M., Cartigny, Y., De Smet, F., Rome, S., Aerts, L., Quéré, L., Wouters, J., & Coquerel, G. (2018). A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules. Crystal Growth and Design, 18(9), 4807-4810. https://doi.org/10.1021/acs.cgd.8b00331