A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules

Nicolas Couvrat, Morgane Sanselme, Yohann Cartigny, Frederic De Smet, Sandrine Rome, Luc Aerts, Luc Quéré, Johan Wouters, Gérard Coquerel

Research output: Contribution to journalArticle

Abstract

This article highlights the unusual behavior of brivaracetam (BRV: An active pharmaceutical ingredient against epilepsy), which leads to a unique phase-ranging from clathrate to solvate to cocrystal-formed with an impressive number of apolar guest molecules (any linear alkanes to esters of fatty acids/alcohols, or waxes). Moreover, the investigation of binary systems between linear alkanes and BRV displayed the systematic existence of a syntectic invariant (one solid melts into two nonmiscible liquids) for CnH2n+2 with n > 7.

Original languageEnglish
Pages (from-to)4807-4810
Number of pages4
JournalCrystal Growth and Design
Volume18
Issue number9
DOIs
Publication statusPublished - 5 Sep 2018

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isomorphism
Alkanes
Paraffins
alkanes
epilepsy
Crystalline materials
Paraffin waxes
Molecules
waxes
Waxes
clathrates
fatty acids
Fatty acids
ingredients
Drug products
esters
molecules
Esters
alcohols
Alcohols

Cite this

Couvrat, Nicolas ; Sanselme, Morgane ; Cartigny, Yohann ; De Smet, Frederic ; Rome, Sandrine ; Aerts, Luc ; Quéré, Luc ; Wouters, Johan ; Coquerel, Gérard. / A Possible Infinite Number of Components in a Single Crystalline Phase : On the Isomorphism of Brivaracetam-Guest Molecules. In: Crystal Growth and Design. 2018 ; Vol. 18, No. 9. pp. 4807-4810.
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Couvrat, N, Sanselme, M, Cartigny, Y, De Smet, F, Rome, S, Aerts, L, Quéré, L, Wouters, J & Coquerel, G 2018, 'A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules', Crystal Growth and Design, vol. 18, no. 9, pp. 4807-4810. https://doi.org/10.1021/acs.cgd.8b00331

A Possible Infinite Number of Components in a Single Crystalline Phase : On the Isomorphism of Brivaracetam-Guest Molecules. / Couvrat, Nicolas; Sanselme, Morgane; Cartigny, Yohann; De Smet, Frederic; Rome, Sandrine; Aerts, Luc; Quéré, Luc; Wouters, Johan; Coquerel, Gérard.

In: Crystal Growth and Design, Vol. 18, No. 9, 05.09.2018, p. 4807-4810.

Research output: Contribution to journalArticle

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