TY - JOUR
T1 - A convergent strategy for the pamamycin macrodiolides
T2 - Total synthesis of pamamycin-607, pamamycin-593, and pamamycin-621D precursors
AU - Lanners, S.
AU - Norouzi-Arasi, H.
AU - Salom-Roig, X.J.
AU - Hanquet, Gilles
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - A convergent total synthesis of pamamycin-607 (1), isolated from Streptomyces alboniger, was achieved by an E-Z isomerization of a tetrahydrofuran alkylidene and a regio- and diastereoselective solvent-dependent cyclo-CHBCl/EtN-mediated aldol reaction as the key steps. The second key step was extended to other ketones, opening the route to new pamamycin macrodiolides, for example, pamamycin-593 and pamamycin-621D. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
AB - A convergent total synthesis of pamamycin-607 (1), isolated from Streptomyces alboniger, was achieved by an E-Z isomerization of a tetrahydrofuran alkylidene and a regio- and diastereoselective solvent-dependent cyclo-CHBCl/EtN-mediated aldol reaction as the key steps. The second key step was extended to other ketones, opening the route to new pamamycin macrodiolides, for example, pamamycin-593 and pamamycin-621D. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
UR - http://www.scopus.com/inward/record.url?scp=34848893572&partnerID=8YFLogxK
U2 - 10.1002/anie.200701749
DO - 10.1002/anie.200701749
M3 - Article
SN - 1433-7851
VL - 46
SP - 7086
EP - 7089
JO - Angewandte Chemie. International edition
JF - Angewandte Chemie. International edition
IS - 37
ER -