A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

Carlo Yague-Sanz, Enrique Vázquez, Mar Sánchez, Francisco Antequera, Damien Hermand

Research output: Contribution to journalArticlepeer-review

Abstract

The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalCurrent Genetics
Early online date24 Aug 2016
DOIs
Publication statusE-pub ahead of print - 24 Aug 2016

Keywords

  • Chromatin
  • Mitosis
  • Nucleosome
  • RSC
  • Yeast

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