A 3D ordered hierarchical crystalline porous organic salt for large-sized enzyme immobilization

Jinman Wang, Guolong Xing, Yu Zhao, Jinming Zhou, Bo Song, Li Hua Chen, Weidong Zhu, Bao Lian Su, Teng Ben

Research output: Contribution to journalArticlepeer-review

Abstract

Crystalline porous organic salts (CPOSs) are an emerging class of promising materials with intrinsic highly polar nanoconfined microporosity. However, their single microporous structure greatly hinders their development in the field of catalysis and adsorption. Constructing a hierarchical porous structure can effectively reduce the mass transport resistance, thus expanding the scope of their applications. Herein, we report the synthesis of a three-dimensional (3D) ordered macro-/microporous hierarchical CPOS (HCPOS-1) using a template-assisted approach for the first time. The as-synthesized HCPOS-1 prepared from a polystyrene colloidal crystal template showcases a 3D ordered macroporous structure while also preserving the microporous structure. The 3D ordered macroporous structure in such a hierarchical structure, together with its hydrophilic surface, endows HCPOS-1 with the ability to i mmobi l i ze l arge-si zed enzymes through physi cal adsorpti on under mi l d condi ti ons. The resul ti ng catalase/HCPOS-1 showcases a high enzyme immobilization capacity and avoids undesired conformational changes of enzymes during the immobilization process, thus exhibiting excellent catalytic activity for the decomposition of hydrogen peroxide.

Original languageEnglish
Article number34
JournalChemical Synthesis
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 2024

Keywords

  • catalysis
  • Crystalline porous organic salts
  • enzyme immobilization
  • hierarchical pores
  • template-assisted method

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