Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • JOHAN WOUTERS
2011

4-Nitro-N-phthalyl-L-tryptophan

Tilborg, A., Boittiaux, I., Norberg, B., Lambert, D. & Wouters, J., 2011, In : Acta Crystallographica. Section E. 67, 8, p. o2116

Research output: Contribution to journalArticle

File
24 Downloads (Pure)

Acid-base modulation of a versatile heteroditopic calix[6]arene based receptor

Cornut, D., Marrot, J., Wouters, J. & Jabin, I., 21 Sep 2011, In : Organic and Biomolecular Chemistry. 9, 18, p. 6373-6384 12 p.

Research output: Contribution to journalArticle

A CONVENIENT FORMATION OF HIGHLY FUNCTIONALIZED 5-BROMO-1,3-THIAZOLES.

Dolusic, E., Modaffari, S., Wouters, J., Masereel, B. & Frédérick, R., 2011, p. Book of Abstracts, 15th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, 1-2 December 2011, p. 25. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
69 Downloads (Pure)

Aromatic Thiosemicarazones are inhibitors of tryptophan 2,3-Dioxygenase (TDO), an emerging target for cancer treatment

Dolusic, E., Modaffari, S., Larrieu, P., Vancraeynest, C., Pilotte, L., Colau, D., Stroobant, V., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2011, (Unpublished) p. Book of Abstracts, ASMC 11, St. Petersburg, Russia, August 21-25, 2011, P157. 1 p.

Research output: Contribution to conferencePoster

File
82 Downloads (Pure)

coauthor on lecture: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase (TDO): discovery of an orally active TDO inhibitor.

Dolusic, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Van den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 2011, Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011: Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011). Vol. OC01. p. OC01

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J-M., Masereel, B., Van Den Eynde, B., Wouters, J. & Frédérick, R., 2011, In : European Journal of Medicinal Chemistry. 46, 7, p. 3058-3065 8 p.

Research output: Contribution to journalArticle

Electrostatically-driven assembly of MWCNTs with a europium complex

Maggini, L., Traboulsi, H., Yoosaf, K., Mohanraj, J., Wouters, J., Pietraszkiewicz, O., Pietraszkiewicz, M., Armaroli, N. & Bonifazi, D., 7 Feb 2011, In : Chemical Communications. 47, 5, p. 1625-1627 3 p.

Research output: Contribution to journalArticle

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Norberg, B., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galeni, M., Frre, J. M., Masereel, B., Van Den Eynde, B., Wouters, J. & Frédérick, R., 15 Feb 2011, In : Bioorganic and Medicinal Chemistry. 19, 4, p. 1550-1561 12 p.

Research output: Contribution to journalArticle

File
539 Downloads (Pure)

Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Dolusic, E., Larrieu, P., Colette, D., Blanc, S., Rives, A., Fraser, G., Wouters, J., Kiss, R., Van den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 2011, Oral Communication, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège: De la conception à la réalisation en pharmacochimie. Vol. OC10. p. 22-22 1 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Open Access
File
49 Downloads (Pure)

Indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2,3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy

Dolusic, E., Larrieu, P., Blanc, S., Moineaux, L., Sapunaric, F., Pouyez, J., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Frère, J-M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, 47èmes RICT, 6-8 juillet 2011, Lyon, France, IS08, p. 136. 1 p.

Research output: Contribution to conferencePoster

File
48 Downloads (Pure)

Indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2,3-dioxygenase (IDO), a promising target for anti-cancer immunotherapy

Dolusic, E., Larrieu, P., Blanc, S., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colaux, D., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2011, p. Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, P37, p. 62. 1 p.

Research output: Contribution to conferencePoster

Inhibition studies on enzymes involved in isoprenoid biosynthesis. focus on two potential drug targets: Dxr and idi-2 enzymes

de Ruyck, J., Wouters, J. & Poulter, C. D., 1 Jul 2011, In : Current Enzyme Inhibition. 7, 2, p. 79-95 17 p.

Research output: Contribution to journalArticle

Interuniversity Scientific Computing Facility

Vigneron, J-P., Champagne, B., Deparis, O., Henrard, L., Lambin, P., Vercauteren, D. P., Wautelet, F. & Wouters, J., 2011, In : Nanotechnologies. p. 101-102 2 p.

Research output: Contribution to journalArticle

Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Target for Anti-Cancer Immunotherapy

Dolusic, E., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2011, p. Book of Abstracts, XVIIIème Journée Jeunes Chercheurs, 04/02/11, Paris, France. 1 p.

Research output: Contribution to conferencePoster

File
78 Downloads (Pure)

Pharmaceutical Salts and Co-crystals

Wouters, J. (ed.) & Quere, L. (ed.), 2011, The Royal Society of Chemistry. (RSC Drug Discovery)

Research output: Book/Report/JournalBook

SYNTHESIS, ACTIVITY, CRYSTAL AND ELECTRONIC PROPERTIES OF ISOMERS OF CHLORO-PYRIDINYLVINYL-1H-INDOLES

Moineaux, L., Laurent, S., Dolusic, E., Reniers, J., Norberg, B., Frère, J-M., Galleni, M., Van den Eynde, B., Masereel, B., Frédérick, R. & Wouters, J., 2011, p. Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, P20, p. 45. 1 p.

Research output: Contribution to conferencePoster

Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: New structural insight into the HIV-1 integrase inhibition

Vandurm, P., Guiguen, A., Cauvin, C., Georges, B., Le Van, K., Michaux, C., Cardona, C., Mbemba, G., Mouscadet, J. F., Hevesi, L., Van Lint, C. & Wouters, J., 1 May 2011, In : European Journal of Medicinal Chemistry. 46, 5, p. 1749-1756 8 p.

Research output: Contribution to journalArticle

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Charlier, P., Laurent, S., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22. 1 p.

Research output: Contribution to conferencePoster

Synthesis and catalytic evaluation of ruthenium-arene complexes bearing imidazol(in)ium-2-thiocarboxylate ligands

Hans, M., Willem, Q., Wouters, J., Demonceau, A. & Delaude, L., 28 Nov 2011, In : Organometallics. 30, 22, p. 6133-6142 10 p.

Research output: Contribution to journalArticle

Synthesis and organocatalytic applications of imidazol(in)ium-2- thiocarboxylates

Hans, M., Wouters, J., Demonceau, A. & Delaude, L., 1 Dec 2011, In : European Journal of Organic Chemistry. 35, p. 7083-7091 9 p.

Research output: Contribution to journalArticle

THIOSEMICARBAZONES AS INHIBITORS OF TRYPTOPHAN 2,3-DIOXYGENASE (TDO), AN EMERGING TARGET FOR CANCER TREATMENT

Dolusic, E., Modaffari, S., Larrieu, P., Vancraeynest, C., Pilotte, L., Colau, D., Stroobant, V., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 2011, p. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 21. 1 p.

Research output: Contribution to conferencePoster

File
154 Downloads (Pure)

Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, p. 19. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
75 Downloads (Pure)

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Pochet, L., Van Den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 11 Aug 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5320-5334 15 p.

Research output: Contribution to journalArticle

2012

Advances in pharmaceutical Co-crystal screening: Effective Co-crystal screening through structural resemblance

Springuel, G., Robeyns, K., Leyssens, T., Norberg, B. & Wouters, J., 1 Jan 2012, In : Crystal Growth and Design. 12, 1, p. 475-484 10 p.

Research output: Contribution to journalArticle

A structural study of the lithiophilite-sicklerite series

Hatert, F., Ottolini, L., Wouters, J. & Fontan, F., 1 Aug 2012, In : Canadian Mineralogist. 50, 4, p. 843-854 12 p.

Research output: Contribution to journalArticle

Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors

Gillet, N., Vandermeers, F., Brogniez, A. D., Florins, A., Nigro, A., François, C., Bouzar, A-B., STERN, E., Lambert, D. M., Wouters, J. & WILLEMS, L., 15 Nov 2012, In : Plos Pathogens. 1, 2, p. 65-82 18 p.

Research output: Contribution to journalArticle

Open Access
File
52 Downloads (Pure)

Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Braga, D., Grepioni, F., Maini, L., Capucci, D., Nanna, S., Wouters, J., Aerts, L. & Quéré, L., 25 Aug 2012, In : Chemical Communications. 48, 66, p. 8219-8221 3 p.

Research output: Contribution to journalArticle

Concluding remarks using piracetam as a learning model

Wouters, J., Tilborg, A. & Quéré, L., 2012, Pharmaceutical Salts and Co-crystals. Cambridge: Royal Society of Chemistry (RSC), Vol. 16. p. 330 - 337 8 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Convenient one-pot formation of highly functionalized 5-halothiazoles

Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
59 Downloads (Pure)

Crystal structures of low-melting ionic transition-metal complexes with N-alkylimidazole ligands

Vander Hoogerstraete, T., Brooks, N. R., Norberg, B., Wouters, J., Van Hecke, K., Van Meervelt, L. & Binnemans, K., 7 Aug 2012, In : CrystEngComm. 14, 15, p. 4902-4911 10 p.

Research output: Contribution to journalArticle

Determination of the Absolute Configuration of Aegelinol by Crystallization of Its Inclusion Complex with β-Cyclodextrin

Elasaad, K., Alkhatib, R., Hennebelle, T., Norberg, B. & Wouters, J., 26 Oct 2012, In : Crystals. 2, 4, p. 1441-1454 14 p.

Research output: Contribution to journalArticle

Open Access
File
65 Downloads (Pure)
4 Downloads (Pure)

Interuniversity Scientific Computing Facility

Vigneron, J-P., Champagne, B., Deparis, O., Henrard, L., Lambin, P., Vercauteren, D. P., Wautelet, F. & Wouters, J., 2012, In : Nanotechnologies. p. 173-174 2 p.

Research output: Contribution to journalLiterature review

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

Frédérick, R., Bruyére, C., Vancraeynest, C., Reniers, J., Meinguet, C., Pochet, L., Backlund, A., Masereel, B., Kiss, R. & Wouters, J., 26 Jul 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6489-6501 13 p.

Research output: Contribution to journalArticle

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolušić, E., Frédérick, R., De Plaen, E., Uyttenhove, C., Wouters, J., Masereel, B. & Van Den Eynde, B. J., 14 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2497-2502 6 p.

Research output: Contribution to journalArticle

Open Access
File
55 Downloads (Pure)

Reversal of Tumoral Immune Resistance by Inhibition of Tryptophan 2,3-Dioxygenase (TDO): Design, Synthesis and Preclinical Evaluation of a Novel TDO Inhibitor.

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colaux, D., Van den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 2012, In : ChemMedChem. p. 371 1 p.

Research output: Contribution to journalLiterature review

Open Access
File
15 Downloads (Pure)

Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Moineaux, L., Laurent, S., Reniers, J., Dolusic, E., Galleni, M., Frère, J-M., Masereel, B., Frédérick, R. & Wouters, J., 1 Aug 2012, In : European Journal of Medicinal Chemistry. 54, p. 95-102 8 p.

Research output: Contribution to journalArticle

Open Access
File
139 Downloads (Pure)

Synthesis of two new alkyne-bearing linkers used for the preparation of siRNA for labeling by click chemistry with fluorine-18

Flagothier, J., Kaisin, G., Mercier, F., Thonon, D., Teller, N., Wouters, J. & Luxen, A., 1 Aug 2012, In : Applied Radiation and Isotopes. 70, 8, p. 1549-1557 9 p.

Research output: Contribution to journalArticle

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors as Anticancer Immunomodulators

Dolusic, E., Larrieu, P., Moineaux, L., Strobant, V., Pilotte, L., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 15 Jul 2012, p. Programme & Book of Abstracts, BOSS XIII, KU Leuven, Belgium, 15 - 20 July 2012, P292, p. 339. 1 p.

Research output: Contribution to conferencePoster

File
236 Downloads (Pure)

Unprecedented copper(I) bifluoride complexes: Synthesis, characterization and reactivity

Vergote, T., Nahra, F., Welle, A., Mager, N., Riant, O., Leyssens, T., Luhmer, M. & Wouters, J., 16 Jan 2012, In : Chemistry: A European Journal. 18, 3, p. 793-798 6 p.

Research output: Contribution to journalArticle

Zavalíaite, (Mn,Fe,Mg)(PO ), a new member of the sarcopside group from the La Empleada pegmatite, San Luis Province, Argentina

Hatert, F., Roda-Robles, E., De Parseval, P. & Wouters, J., 1 Dec 2012, In : Canadian Mineralogist. 50, 6, p. 1445-1452 8 p.

Research output: Contribution to journalArticle

2013

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
97 Downloads (Pure)