5-substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase

Johan Wouters, Piet Herdewijn

Research output: Contribution to journalArticle

Abstract

Conformational analysis of anhydrohexitol nucleosides using a combination of experimental (X-ray crystallography) and computational methods indicates that those antiviral compounds occur in an equilibrium between two forms, one conformation being adopted in solid phase and in solution, the other found when the nucleosides are in complex with HSV-1 thymidine kinase. The conformational change induced by the enzyme has been investigated.

Original languageEnglish
Pages (from-to)1563-1566
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume9
Issue number11
DOIs
Publication statusPublished - 7 Jun 1999

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