(2RS,5SR,6SR)-Methyl 4-{cis-2-[3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H- pyran-4-yl)phenoxymethyl]-6-hydroxy-3-phenylmorpholino}benzenesulfinate

Caroline Charlier, Aurelie Delayen, Bernadette Norberg, Jean Pierre Hénichart, Johan Wouters

Research output: Contribution to journalArticlepeer-review

Abstract

The title compound, C 30H 34FNO 7S, is a key intermediate in the design of dual 5-LOX (5-lipoxygenase)/COX-2 (cyclooxygenase-2) inhibitors. The compound crystallizes as a racemate. Linear hydrogen-bonded chains are aligned along the [201] direction, and stacked π-π interactions and C - H⋯O contacts stabilize the crystal structure.

Original languageEnglish
JournalActa crystallographica Section C: Crystal Structure communications
Volume62
Issue number2
DOIs
Publication statusPublished - 1 Feb 2006

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