Transcriptional regulation in hypoxia : role of HIF-1

Project: PHD

Project Details


Several aspects of hypoxia-mediated regulation of gene transcription are investigated. We are investigating kinase pathways involved in HIF-1 phosphorylation. A new project is aimed to identify new proteins interacting with HIF-1 by a two-hybrid screen as well as by 2-D gels. We are also identifiying the amino acids involved in direct contacts with DNA through computational modeling and site-directed mutagenesis.
Effective start/end date1/09/9720/12/00


  • gene expression
  • structural studies
  • HIF-1
  • kinases
  • hypoxia


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