Project Details
Description
Several aspects of hypoxia-mediated regulation of gene transcription are investigated. We are investigating kinase pathways involved in HIF-1 phosphorylation. A new project is aimed to identify new proteins interacting with HIF-1 by a two-hybrid screen as well as by 2-D gels. We are also identifiying the amino acids involved in direct contacts with DNA through computational modeling and site-directed mutagenesis.
| Status | Finished |
|---|---|
| Effective start/end date | 1/09/97 → 20/12/00 |
Keywords
- gene expression
- structural studies
- HIF-1
- kinases
- hypoxia
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.