Synthesis of a novel Nickel pincer nucleotide and its biosynthetic precursors

Project: Research


A novel biochemical cofactor has been recently discovered by the UCL
team. This molecule is a nucleoside monophosphate featuring a unique CNi
bond at the nucleobase. Its biosynthesis, also recently discovered,
involves three enzymes whose original and unclear mechanisms address
important questions in fundamental enzymology. The present project
proposes: 1) to disclose the first chemical synthesis of the newly discovered
cofactor and its two direct biosynthetic precursors 2) to generate close
analogues of the cofactor and its biosynthetic precursors designed as
mechanistic probes of the 4 enzymes involved in this unique biosynthetic
pathway 3) to study the intimate enzymatic mechanisms and to determine
the binding modes of these biomolecules.
Short titleNickel Pincer Cofactor
Effective start/end date1/01/1831/12/21