Study of the retrograde molecular communication induced by lysosomal storage

Project: PHD

Project Details

Description

Study of the communication between lysosomes and nuclei. Two major approaches will be developped to identify new transcription factors involved in cell response to a lysosomal dysfunction and to study their functional role in the modifications that are induced.Animal models and cell lines derived from patients affected by lysosomal storage diseases will also be used.
StatusFinished
Effective start/end date1/10/0430/09/08

Keywords

  • gene expression
  • cell signaling
  • transcription factors
  • lysosomes
  • nucleus