Study of the complementarity between ligands/receptors and protein/DNA by the development of genetic algorithm methods

Project: PHD

Description

A genetic algorithm (GA) method is elaborated to study the "HIV-1 reverse transcriptase/non-nucleoside inhibitors", "cyclodextrine/chiral drug", and "DNA/protein" systems. Each potential position and orientation of the ligand in the receptor active site is evaluated by a function based on the compatible contacts between host and guest.
StatusFinished
Effective start/end date1/09/9831/12/04

Keywords

  • artificial intelligence
  • DNA
  • complementarity
  • protein
  • non-nucleoside inhibitor
  • HIV-1 RT
  • genetic algorithms