A genetic algorithm (GA) method is elaborated to study the "HIV-1 reverse transcriptase/non-nucleoside inhibitors", "cyclodextrine/chiral drug", and "DNA/protein" systems. Each potential position and orientation of the ligand in the receptor active site is evaluated by a function based on the compatible contacts between host and guest.
|Effective start/end date||1/09/98 → 31/12/04|
- artificial intelligence
- non-nucleoside inhibitor
- HIV-1 RT
- genetic algorithms