Angiotensin II is an octapeptide which possesses potent vasoconstrictor properties. Non-peptide AT1-selective angiotensin II receptor antagonists have been developed to treat hypertension. A comparative analysis of their structural and electronic properties leads us to generate pharmacophore models.
|Effective start/end date||30/09/94 → 31/12/00|
- angiotensin II
- AT1 receptor
- conformational analysis
- structural analysis