Role of endophilin-A3-dependent endocytosis and its cargo CD166 in cancer

Project: Research

Project Details


Endophilin-A3 (EndoA3) is part of the BAR (Bin/Amphiphysin/Rvs) domain protein superfamily, specialized in membrane curvature sensing/induction. EndoA3 has recently been highlighted by my host lab as one of the main players in a novel clathrin-independent endocytic (CIE) mechanism. This pathway regulates cell surface homeostasis of CD166, a tumor marker which is an immunoglobulin-like protein involved in cell-cell and cell-surface interactions. The aim of this porject is to study the involvement of the endophilin-A3-dependent endocytosis and its cargo CD166 in cancer.
Effective start/end date15/09/20 → …

Attachment to an Research Institute in UNAMUR



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